O1002
苯唑西林 钠盐 一水合物
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线性分子式:
C19H18N3O5SNa · H2O
化学文摘社编号:
分子量:
441.43
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
EC Number:
214-636-3
Beilstein/REAXYS Number:
4287093
MDL number:
InChI key
ZVIYWUUZWWBNMB-VICXVTCVSA-M
InChI
1S/C19H19N3O5S.Na.H2O/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22;;/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
SMILES string
[Na+].[H]O[H].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c3c(C)onc3-c4ccccc4)C([O-])=O
form
powder
solubility
water: 50-52 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
2-8°C
Quality Level
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Application
Oxacillin sodium salt monohydrate has been used in penicillin (PEN) standards. In turbidimetric method, oxacillin sodium salt monohydrate has been used in the medium with antibiotic.
Biochem/physiol Actions
Oxacillin and its derivatives are released through urine with the help of glomerular filtration and tubular secretion. It can be used in nursing mothers. Oxacillin is used in the treatment of methicillin-susceptible S. aureus (MSSA) infections. It shows resistance to penicillinase.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
Drugs and Lactation Database (LactMed) (2006)
An easy-to-use, rapid and inexpensive method to determine methicillin resistance in Staphylococcus aureus.
Gocmen JS, et al.
Journal of Clinical and Experimental Investigations, 7(3), 225-251 (2016)
The Washington Manual Infectious Diseases Subspecialty Consult, 352-352 (2005)
Nancy Tawil et al.
Biosensors & bioelectronics, 49, 334-340 (2013-06-26)
Two hundred fifty Staphylococcus aureus clinical isolates were studied to determine their susceptibilities to β-lactam antibiotics. Among these isolates, 16 were methicillin-sensitive S. aureus (MSSA), 207 were methicillin-resistant S. aureus (MRSA) and 27 were borderline oxacillin-resistant S. aureus (BORSA). Currently
Galoz Kaneti et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(12), 4834-4843 (2013-08-24)
In previous studies, the oligo-acyl-lysyl (OAK) C12(ω7)K-β12 added to cultures of gram-positive bacteria exerted a bacteriostatic activity that was associated with membrane depolarization, even at high concentrations. Here, we report that multidrug-resistant Staphylococcus aureus strains, unlike other gram-positive species, have
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