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PHR1153

Supelco

柠檬酸三乙酯

Pharmaceutical Secondary Standard; Certified Reference Material

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别名:
柠檬酸乙酯
线性分子式:
HOC(COOC2H5)(CH2COOC2H5)2
CAS号:
77-93-0
分子量:
276.28
Beilstein:
1801199
EC 号:
201-070-7
MDL编号:
MFCD00009201
PubChem化学物质编号:
329823171
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to USP 1683606

蒸汽密度

9.7 (vs air)

蒸汽压

1 mmHg ( 107 °C)

API family

triethyl citrate

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

折射率

n20/D 1.442 (lit.)

bp

235 °C/150 mmHg (lit.)

密度

1.14 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

CCOC(=O)CC(O)(CC(=O)OCC)C(=O)OCC

InChI

1S/C12H20O7/c1-4-17-9(13)7-12(16,11(15)19-6-3)8-10(14)18-5-2/h16H,4-8H2,1-3H3

InChI key

DOOTYTYQINUNNV-UHFFFAOYSA-N

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相关类别

一般描述

Triethyl citrate is an ester of citric acid and is commonly used as a plasticizer in pharmaceutical coatings including tablets, capsules, beads and granules for masking taste. It is also used as a flavoring agent in food.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Triethyl citrate can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.

分析说明

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Values of analytes vary lot to lot.

附注

To see an example of a Certificate of Analysis for this material enter LRAA8988 in the slot below. This is an example certificate only and may not be the lot that you receive.

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

311.0 °F - closed cup

闪点(°C)

155 °C - closed cup

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Oral Strip Technology: A review
Jaiswal, Hema
Indian Journal of Pharmaceutical and Biological Research, 2(2), 130-130 (2014)
Ethylcellulose--A Pharmaceutical Excipient with Multidirectional Application in Drug Dosage Forms Development
Wasilewska K and Winnicka K
Materials, 12(20), 3386-3386 (2019)
Detection and quantification of low-molecular-weight aldehydes in pharmaceutical excipients by headspace gas chromatography
Li Z, et al.
Journal of Chromatography A, 1104(1-2), 1-10 (2006)
Development and validation of a gradient HPLC method for the determination of clindamycin and related compounds in a novel tablet formulation.
Platzer DJ, White BA.
Journal of Pharmaceutical and Biomedical Analysis, 41(1), 84-88 (2006)
Gavin P Andrews et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 69(1), 264-273 (2008-01-01)
The aim of this highly novel study was to use hot-melt extrusion technology as an alternative process to enteric coating. In so doing, oral dosage forms displaying enteric properties may be produced in a continuous, rapid process, providing significant advantages
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