Monoclonal Anti-Brain-derived Neurotrophic Factor antibody produced in mouse

Brain derived neurotrophic factor (BDNF) belongs to a family of secreted proteins called neurotrophins that includes, nerve growth factor (NGF), neurotrophin-3 (NT3) and NT4/5. BDNF is expressed in the developing and the mature brain. The influence of BDNF is mediated by its binding to TrkB receptor and sometimes the receptor p75^NTR. The downstream pathways promoted by BDNF include PI3K, MAPK and JAK/STAT. The most important role of BDNF is the regulation of synaptic transmission and plasticity, protein synthesis and phosphorylation of local proteins. The secretion of BDNF is highly regulated at both transcriptional and translational levels since it is involved in the proper function of neuronal circuit and development of cognitive functions. The deficits in BDNF functions are implicated in a number of neurodegenerative disorders such as Huntington′s disease, schizophrenia and dementia
Monoclonal Anti-Brain-derived Neurotrophic Factor detects human BDNF.

purified, Sf21-derived recombinant human brain-derived neurotrophic factor.

Monoclonal Anti-Brain-derived Neurotrophic Factor may be used to detect human BDNF by flow cytometry using a working antibody concentration of 25 μg/ml.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

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