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H0135

氢化可的松

γ-irradiated, powder, BioXtra, suitable for cell culture

别名:

11β,17α,21-三羟基孕酮-4-烯-3,20-二酮, 17-羟基皮质酮标准液, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 皮质醇标准液, 肯德尔氏化合物F, 赖希斯坦氏物质M

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关于此项目

经验公式（希尔记法）:
C21H30O5
化学文摘社编号:
50-23-7
分子量:
362.46
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
24895394
EC Number:
200-020-1
Beilstein/REAXYS Number:
1354819
MDL number:
MFCD00011654
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥80% (HPLC)
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biological source

synthetic (organic)

Quality Level

200

sterility

γ-irradiated

product line

BioXtra

assay

≥80% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

mp

211-214 °C (lit.)

solubility

ethanol: 1 mg/mL, clear

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)

General description

用于上皮和内皮贴壁细胞培养的氢化可的松。

Application

氢化可的松可用于以下应用：
  • 用于肌原性的诱导和鉴定
  • 用于长期基质培养和甲基纤维素培养（作为培养基中的成分之一）
  • 用于成脂分化（作为成脂培养基中的成分之一）
  • 用于细胞培养：将人乳腺上皮细胞MCF-10A细胞保存在补充有氢化可的松及其他成分的DMEM/F12中
  • SUM149细胞系是从原始IBC建立的，并在补充有FBS的含胰岛素和氢化可的松的Ham′s F12培养基中进行生长
  • 可用于黑色素瘤球状细胞的分化测定中

Biochem/physiol Actions

肾上腺皮质分泌的原始糖皮质激素。
肾上腺皮质分泌的原始糖皮质激素。它的抗炎效力是皮质酮的三倍，但 Na2+ 保留效力要低得多。

Physical form

室温下为粉末状；分成小份冻存，以避免使用时反复冷冻/解冻

Preparation Note

要制备 50μg/mL 的储存液，可加入 1mL 无水乙醇，温和搅拌使之溶解，在搅拌下加入 19mL 无菌培养基。

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pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1A - STOT RE 2

target_organs

Adrenal gland,Bone marrow

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000469978
0000469978
0000401913
0000401913
0000382678

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Q L Hao et al.
Blood, 86(10), 3745-3753 (1995-11-15)
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K L van Golen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 5(9), 2511-2519 (1999-09-28)
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货号GTIN
H0135-1MG04061833662649