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H9772

5-羟基L-色氨酸

Name: 5-羟基<SC>L</SC>-色氨酸
Brand: SIGMA

≥98% (TLC), suitable for HPLC

别名:

L -2-氨基-3-（5-羟基吲哚基）丙酸, L--5-HTP

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关于此项目

经验公式（希尔记法）:

C₁₁H₁₂N₂O₃

化学文摘社编号:

4350-09-8

分子量:

220.22

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24278131

NACRES:

NA.77

EC Number:

224-411-1

MDL number:

MFCD00064341

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属性

产品名称

5-羟基L-色氨酸, powder

assay

≥98% (TLC)

Quality Level

200

form

powder

technique(s)

HPLC: suitable

color

white to faint beige

storage temp.

2-8°C

SMILES string

N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(O)=O

InChI

1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1

InChI key

LDCYZAJDBXYCGN-VIFPVBQESA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

说明

General description

5-羟基-L-色氨酸(5-HTP)天然存在于加纳籽(Griffonia simplicifolia)中。

Application

5-羟基-L-色氨酸已用于：

注射实验小鼠进行血清素检测
作为5-羟色胺前体注入怀孕小鼠和新生大鼠，用于进行肺切片的中性红活体染色
作为柠檬酸-乙酸缓冲液用标准品，用于高效液相色谱(HPLC)分析。

Biochem/physiol Actions

L-色氨酸的羟化反应在大脑的血清素合成过程中进行。该步骤调控血清素的生产，并生成5-羟基-l-色氨酸(5-HTP)代谢物。因此服用5-羟色氨酸(5-HTP)会提高血清素水平，导致抑郁、睡眠不足和剧烈头痛。

血清素的直接前体； L -芳香族氨基酸脱羧酶底物。

Disclaimer

感光

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pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

血清素合成及代谢

血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。

Enhanced synthesis of 5-hydroxy-l-tryptophan through tetrahydropterin regeneration

Hara R and Kino K

AMB Express, 3(1), 70-70 (2013)

Sex differences in aggression: Differential roles of 5-HT2, neuropeptide F and tachykinin.

Andrew N Bubak et al.

PloS one, 14(1), e0203980-e0203980 (2019-01-30)

Despite the conserved function of aggression across taxa in obtaining critical resources such as food and mates, serotonin's (5-HT) modulatory role on aggressive behavior appears to be largely inhibitory for vertebrates but stimulatory for invertebrates. However, critical gaps exist in

Increasing serotonin bioavailability alters gene expression in peripheral leukocytes and lymphoid tissues of dairy calves.

M G Marrero et al.

Scientific reports, 10(1), 9712-9712 (2020-06-18)

Dairy calves are born with a naïve immune system, making the pre-weaning phase a critical window for immune development. In the U.S., 40-60% of dairy farms feed milk replacer to pre-weaned calves, which are devoid of bioactive factors with immunological

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全球贸易项目编号

货号	GTIN
H9772-1G	04061833813157
H9772-250MG	04061832416625
H9772-25G	04061833813171
H9772-5G	04061832416649
H9772-100MG	04061833813126