biological source
Salmonella enterica (Serotype abortus equi)
Quality Level
form
lyophilized powder
purified by
phenol extraction
impurities
<3% Protein (Lowry)
color
white to faint gray
solubility
water: soluble
shipped in
ambient
storage temp.
2-8°C
General description
本品是从马流产沙门氏菌中提取的苯酚。源菌株是ATCC 9842。来自马流产沙门氏菌的脂多糖刺激人单核细胞产生肿瘤坏死因子。这种LPS对青蛙和小鼠淋巴细胞也具有促有丝分裂作用。
Application
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征性成分。LPS及其脂质A部分可通过Toll样受体4（TLR4）刺激先天免疫系统细胞，TLR4是Toll样受体蛋白家族的成员，它能识别常见的病原体相关分子模式（PAMP）。
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且暴露在无包膜菌株的细胞表面。它们有助于维持外层膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的破坏。
Preparation Note
本品溶于水(5 mg/ml)或细胞培养基（1 mg/ml），得到浑浊的淡黄色溶液。以盐水为溶剂时，经过涡旋并加热至70-80 oC后，得到浓度更高但仍然浑浊的溶液（20 mg/ml）。脂多糖分子可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中，可观察到混浊的溶液。使用有机溶剂不会得到更澄清的溶液。以甲醇为溶剂将得到含漂浮物的混浊悬浮液，而以水为溶剂将得到均匀的混浊溶液。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L5886-10MG | 04061833958483 |
| L5886-100MG | 04061833274989 |