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Merck
CN

S8071

丹酚 A

≥98% (HPLC), solid

别名:

(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(乙酰氧基)-2-(3-呋喃基)十二氢-6a,10b-二甲基-4,10-二氧代-2H-萘[2,1 -c]吡喃-7-羧酸甲酯

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关于此项目

经验公式（希尔记法）:
C23H28O8
化学文摘社编号:
83729-01-5
分子量:
432.46
NACRES:
NA.77
PubChem Substance ID:
24899776
UNSPSC Code:
12352200
MDL number:
MFCD05664742

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InChI key

OBSYBRPAKCASQB-AGQYDFLVSA-N

SMILES string

[H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(C)=O)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c4ccoc4)C(=O)OC

InChI

1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada; Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage condition

protect from light

color

white

solubility

DMSO: ≥10 mg/mL, ethanol: ~3 mg/mL

storage temp.

−20°C

Quality Level

100

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
rat ... Oprk1(29335)

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相关类别

Application

给予大鼠Salvinorin A来研究其对乳酸刺激的拉伸的影响。1

Biochem/physiol Actions

Salvinorin A是一种无氮κ阿片类选择性受体激动剂。
Salvinorin A是一种有效的无氮κ阿片类选择性受体激动剂。Salvinorin A分离自墨西哥鼠尾草。Salvinorin A在天然（Ki = 4.3 nm）和克隆的（Ki = 16 nm）κ -阿片受体上均表现出高亲和力。初步研究表明，Salvanorin A在精神药物中具有独特的化学性质并不与任何已知受体结合。

Features and Benefits

《受体分类和信号转导》手册的 阿片类药物受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCW9510
MKCT3685
MKCP8805
MKCM8644
MKCL7574

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Zhenhong Wang et al.
PloS one, 7(7), e41724-e41724 (2012-08-23)
Cerebral hypoxia/ischemia (HI) is not uncommon during the perinatal period. If occurring, it can result in severe neurologic disabilities that persist throughout life. Salvinorin A, a non-opioid Kappa opioid receptors (KOR) selective agonist, has the potential to address this devastating
Eduardo R Butelman et al.
The Journal of pharmacology and experimental therapeutics, 341(3), 802-808 (2012-03-22)
Active blood-brain barrier mechanisms, such as the major efflux transporter P-glycoprotein (mdr1), modulate the in vivo/central nervous system (CNS) effects of many pharmacological agents, whether they are used for nonmedical reasons or in pharmacotherapy. The powerful, widely available hallucinogen salvinorin
Katherine A MacLean et al.
Psychopharmacology, 226(2), 381-392 (2012-11-09)
Salvinorin A is a kappa opioid agonist and the principal psychoactive constituent of the plant Salvia divinorum, which has increased in popularity as a recreational drug over the past decade. Few human studies have examined salvinorin A. This double-blind, placebo-controlled
Mitchell T Harden et al.
Behavioural pharmacology, 23(7), 710-715 (2012-08-29)
Salvinorin A (SalvA), the hallucinogenic derivative of the plant Salvia divinorum, is a selective κ-opioid receptor agonist that may also have antidepressant properties. Chronic mild stress (CMS) was applied to male and female Long-Evans rats to model anhedonia common in
Ivo Moreno et al.
Bioanalysis, 5(6), 661-668 (2013-03-15)
The aim of this work was to develop and validate a method for the determination of Salvinorin A in human urine using microextraction by packed sorbent (MEPS) and GC-MS/MS. The technique uses a sample volume as low as 0.2 ml
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