SAB4200155
Anti-Importin 9 (N-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-IMP9, Anti-IPO9, Anti-RANBP9, Anti-Ran-binding protein 9
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Species reactivity:
human
Conjugate:
unconjugated
Application:
IF, IP, WB
Citations:
5
mol wt
antigen ~120 kDa
species reactivity
human
concentration
~1.0 mg/mL
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
technique(s)
immunoprecipitation (IP): 5.0-10 μg, indirect immunofluorescence: 1.25-2.5 μg/mL using fixed HEK-293T cells, western blot: 1-2 μg/mL using HeLa cell lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IPO9(55705)
mouse ... Ipo9(226432)
rat ... Ipo9(304817)
General description
Importin 9 (IPO9) is encoded by the gene mapped to human chromosome 1q32.1. The encoded protein is a molecular transporter and chaperone and is a member of karyopherins super-family. IPO9 has a molecular weight of ~110kDa.
Immunogen
synthetic peptide corresponding to amino acids 90-105 of human Importin 9 conjugated to KLH. The corresponding sequence is identical in mouse and rat.
Application
Anti-Importin 9 (N-terminal) antibody produced in rabbit may be used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
Biochem/physiol Actions
Anti-Importin 9 (N-terminal) recognizes human Importin 9.
Importin 9 (IPO9) promotes transcriptional activity by actively regulating nuclear actin levels. The encoded protein facilitates transport of ribosomal proteins and core histones into the nucleus. Additionally, it acts as an import receptor for c-Jun. Elevated expression of Ipo9 decreased and knockdown of Ipo9 increased basal type I interferon (IFN)-ε expression.
Importin 9 is an import factor for many proteins, including the hepatocellular carcinoma associated protein, core histone H2B and the heat shock protein, HSP27.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Active maintenance of nuclear actin by importin 9 supports transcription.
Dopie J
Proceedings of the National Academy of Sciences of the USA, 109, E544-E552 (2012)
Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-? expression.
Matsumiya T
Journal of Immunology, 191, 1907-1915 (2013)
Nuclear Import of c-Jun Is Mediated by Multiple Transport Receptors
Waldmann I
The Journal of Biological Chemistry, 282, 27685-27692 (2007)
Screening of tumor suppressor genes on 1q31.1-32.1 in Chinese patients with sporadic colorectal cancer.
Zhou CZ
Chinese Medical Journal (English Edition), 121, 2479-2486 (2008)
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains
Jakel S, et al.
The Embo Journal, 21(3), 377-386 (2002)
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