Anti-TIE2, C-Terminal antibody produced in rabbit

Anti-TIE2 Antibody detects endogenous levels of total TIE2 protein.

The TIE2 (TEK receptor tyrosine kinase) gene is mapped to human chromosome 9p21.2. It is predominantly expressed in the Schlemm′s canal endothelial of the eye.

The antiserum was produced against synthesized peptide derived from human TIE2.

Immunogen Range: 1068-1117

Tie-2 (TEK receptor tyrosine kinase) protein induces angiogenesis (both developmental and tumor) and supports endothelial cell survival, upon binding of angiopoietin-1 (an endothelial growth factor) to the receptor. Tie-2 is necessary for Schlemm′s canal formation. The gene regulates vascular homeostasis by involving in auto or transphosphorylation.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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