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SML2283

来那度胺

Name: 来那度胺
Brand: SIGMA

≥98% (HPLC), powder, cereblon binder

别名:

来那度胺, 1-氧-4-氨基-2-(2,6-二氧哌啶-3-基)异吲哚, 3-(4-氨基-1,3-二氢-1-氧代-2H-异吲哚-2-基)-2,6-哌啶二酮, 3-(4-氨基-1-氧代异吲哚-2-基)哌啶-2,6-二酮, CC 5013, CC-5013

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₃N₃O₃

化学文摘社编号:

191732-72-6

分子量:

259.26

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD07772307

Assay:

≥98% (HPLC)

Form:

powder

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属性

产品名称

来那度胺, ≥98% (HPLC)

ligand

lenalidomide

assay

≥98% (HPLC)

form

powder

reaction suitability

reagent type: ligand

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N

InChI

1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)

InChI key

GOTYRUGSSMKFNF-UHFFFAOYSA-N

说明

Biochem/physiol Actions

来那度胺，沙利度胺的一种衍生物，是经批准可用于治疗多发性骨髓瘤的一种免疫调节剂。显然，来那度胺是泛素E3连接酶cereblon的一种配体，可诱导该酶降解Ikaros转录因子IKAROS家族锌指1（IKZF1）和IKZF3。来那度胺具有多效抗肿瘤作用。它可用于治疗5q缺失相关骨髓增生异常综合症（del(5q)-MDS）。

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pictograms

GHS08

signalword

Danger

hcodes

H360D,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B - STOT RE 2

target_organs

Blood

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000413531

0000396751

0000245726

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The CXCR4-STAT3-IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide.

Hila Shaim et al.

Frontiers in immunology, 8, 1773-1773 (2018-01-31)

Chronic lymphocytic leukemia (CLL) cells possess regulatory functions comparable to those of normal B10 cells, a regulatory B cell subset that suppresses effector T-cell function through STAT3-mediated IL-10 production. However, the mechanisms governing IL-10 production by CLL cells are not

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

Donovan KA, et al.

eLife, 7, e38430-e38430 (2018)

Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma.

Antoine Domenger et al.

Frontiers in oncology, 13, 1110916-1110916 (2023-02-14)

Multiple Myeloma (MM) is an incurable neoplasm of mature B cells and the second most prevalent hematological malignancy worldwide. While combinations of proteasome inhibitors like bortezomib (Bz) and immunomodulators (IMiDs) like lenalinomide (Len) are generally effective in newly diagnosed patients

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全球贸易项目编号

货号	GTIN
SML2283-100MG	04061835307111
SML2283-250MG	04061835307128