T1500

睾酮

Name: 睾酮
Brand: SIGMA

≥98%

别名:

17β-羟基-3-氧代-4-雄甾烯, 17β-羟基-4-雄甾烯-3-酮, 4-雄甾烯β-17-醇-3-酮, 反式睾酮

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₈O₂

化学文摘社编号:

58-22-0

分子量:

288.42

UNSPSC Code:

51111800

NACRES:

NA.77

PubChem Substance ID:

24899970

EC Number:

200-370-5

Beilstein/REAXYS Number:

1915399

MDL number:

MFCD00003654

Assay:

≥98%

Form:

powder

Quality level:

200

主要文件

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biological source

synthetic (organic)

Quality Level

200

sterility

non-sterile

assay

≥98%

form

powder

drug control

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 18.2 mg/ml, absolute ethanol: soluble 0.5 mg/ml, chloroform: soluble 100 mg/mL, clear, colorless to very faintly yellow, H₂O: insoluble, dioxane: soluble, methanol: soluble, methyl oleate: slightly soluble, vegetable oils: soluble

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

InChI key

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

Gene Information

human ... AR(367), EBP(10682), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462)
mouse ... Esr1(13982)
rat ... Ar(24208), Esr1(24890), Nr3c1(24413), Nr3c2(25672), Pgr(25154)

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Application

睾丸激素已用作研究雄性和雌性大鼠大脑中类固醇激素发育情况的标准品。该激素也已用于评估其对小鼠肌肉质量和信号传导的作用。

Biochem/physiol Actions

睾丸分泌的睾酮在目标组织中转变为双氢睾酮，介导睾酮的多种生物作用。雄激素诱导胚胎发生和青春期的男性表型发育。

Features and Benefits

该化合物是ADME Tox研究推荐产品。点击此处，查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

该化合物是受体分类及信号转导手册上核受体（类固醇）页面上的特色化合物。想要浏览手册的其他页面，请单击此处。

Preparation Note

睾丸激素以 100 mg/ml 的浓度溶于氯仿中，得到透明、无色至微弱的黄色溶液。它也可溶于甲醇、无水乙醇（0.5 mg/ml）、45％（w/v）2-羟丙基-b-环糊精水溶液（18.2 mg/ml）、植物油和二恶烷。微溶于油酸甲酯，不溶于水。

pictograms

GHS08,GHS07,GHS09

signalword

Danger

hcodes

H302,H351,H360FD,H400

pcodes

P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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Voluntary running, skeletal muscle gene expression, and signaling inversely regulated by orchidectomy and testosterone replacement.

Chikwendu Ibebunjo et al.

American journal of physiology. Endocrinology and metabolism, 300(2), E327-E340 (2010-11-04)

Declines in skeletal muscle size and strength, often seen with chronic wasting diseases, prolonged or high-dose glucocorticoid therapy, and the natural aging process in mammals, are usually associated with reduced physical activity and testosterone levels. However, it is not clear

Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain.

Anne T M Konkle et al.

Endocrinology, 152(1), 223-235 (2010-11-12)

The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex

Oxytocin increases the likeability of physically formidable men.

Frances S Chen et al.

Social cognitive and affective neuroscience, 10(6), 797-800 (2014-09-07)

Physical size and strength are associated with dominance and threat. The current study tested (i) whether men's evaluations of male strangers would be negatively influenced by cues indicating physical formidability, and (ii) whether these evaluations would be influenced by oxytocin

Zinc mediates the action of androgen in acting as a downstream effector of luteinizing hormone on oocyte maturation in zebrafish†.

Jianzhen Li et al.

Biology of reproduction, 100(2), 468-478 (2018-11-13)

The role of androgenic steroids on ovarian development has attracted much attention in recent years, but the molecular mechanism is still largely unknown. In this study, using zebrafish as a model, we found that the trace metal zinc mediates the

The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis.

Y Zimmerman et al.

Human reproduction update, 20(1), 76-105 (2013-10-02)

BACKGROUND; Combined oral contraceptives (COCs) reduce levels of androgen, especially testosterone (T), by inhibiting ovarian and adrenal androgen synthesis and by increasing levels of sex hormone-binding globulin (SHBG). Although this suppressive effect has been investigated by numerous studies over many

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全球贸易项目编号

货号	GTIN
T1500-25G	04061832868691
T1500-1G	04061826694497
T1500-5G	04061832868707

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睾酮

≥98%

选择尺寸

关于此项目

主要文件

属性

biological source

Quality Level

sterility

assay

form

drug control

solubility

shipped in

storage temp.

SMILES string

InChI

InChI key

Gene Information

相关类别

说明

Application

Biochem/physiol Actions

Features and Benefits

Preparation Note

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

wgk

ppe

法规信息

文件

分析证书(COA)

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