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T8552

曲古抑菌素A

From Streptomyces sp., ≥98% (HPLC), Histone deacetylase (HDAC) inhibitor, powder

别名:

TSA, [R-(E,E)]-7-[4-（二甲氨基）苯基]-N-羟基-4,6-二甲基-7-氧代-2,4-庚二烯酰胺

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关于此项目

经验公式（希尔记法）:
C17H22N2O3
化学文摘社编号:
58880-19-6
分子量:
302.37
UNSPSC Code:
12352200
PubChem Substance ID:
24900542
NACRES:
NA.77
MDL number:
MFCD03848392
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
300
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产品名称

曲古抑菌素A, ≥98% (HPLC), from Streptomyces sp.

biological source

Streptomyces sp.

Quality Level

300

assay

≥98% (HPLC)

form

powder

solubility

methanol: soluble 1.90-2.10 mg/mL, clear, colorless to faint yellow or tan, DMF: soluble, DMSO: soluble, H2O: insoluble, acetone: slightly soluble, acetonitrile: soluble, benzene: slightly soluble, chloroform: slightly soluble, ethanol: soluble, ethyl acetate: slightly soluble, lower alcohols: soluble

storage temp.

−20°C

SMILES string

C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C

InChI

1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1

InChI key

RTKIYFITIVXBLE-QEQCGCAPSA-N

Gene Information

human ... HDAC1(3065), HDAC4(9759), HDAC6(10013), HDAC8(55869)
mouse ... ENSMUSG00000061062(15181)
rat ... Hdac7a(84582)

General description

曲古抑菌素A(TSA)是一种强效的特异性组蛋白去乙酰化酶(HDAC)抑制剂。作为抗真菌抗生素，在哺乳动物细胞培养中具有细胞生长抑制和分化诱导作用。

Application

曲古抑菌素A(TSA)已用于克隆小鼠胚胎生产。TSA还用作LNCaP人前列腺癌细胞以及MON和HeLa细胞的组蛋白去乙酰化酶(HDAC)抑制剂。

Biochem/physiol Actions

曲古抑菌素A(TSA)可抑制纳摩浓度的组蛋白脱乙酰基酶造成组蛋白高度乙酰化，使得染色质松弛并调节基因表达。可能参与多种细胞类型细胞周期过程，诱导G和G/M期细胞生长停滞；可能诱导细胞凋亡。增强靶向DNA的抗癌症剂的效力。曲古抑菌素A可作为表观遗传修饰剂。
曲古抑菌素A可抑制纳摩浓度的组蛋白脱乙酰基酶；组蛋白高乙酰化生成物会导致染色质弛豫并调节基因表达。

Features and Benefits

该化合物是细胞凋亡和基因调控研究的特色产品。发现更多细胞凋亡和基因调控特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

Preparation Note

曲古抑菌素A可溶于甲醇，浓度为1.90 - 2.10 mg/ml，并生成一种透明无色至淡黄色/棕黄色的溶液。也可溶于二甲基亚砜(DMSO)、二甲基甲酰胺(DMF)、乙腈、乙醇和低级醇。曲古抑菌素A略溶于氯仿、乙酸乙酯、丙酮和苯。但不溶于水。

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存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000492907
0000492907
0000396985
0000396985
0000382194

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Cancer research, 67(6), 2626-2631 (2007-03-17)
Recent evidence has accumulated that the dynamic histone methylation mediated by histone methyltransferases and demethylases plays key roles in regulation of chromatin structure and transcription. In the present study, we show that SET and MYND domain-containing protein 3 (SMYD3), a
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Clinical cancer research : an official journal of the American Association for Cancer Research, 7(4), 971-976 (2001-04-20)
Trichostatin A (TSA), an antifungal antibiotic with cytostatic and differentiating properties in mammalian cell culture, is a potent and specific inhibitor of histone deacetylase (HDAC) activity. The purpose of this study was to evaluate the antiproliferative and HDAC inhibitory activity
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Fibro-adipogenic progenitors (FAPs) are important components of the skeletal muscle regenerative environment. Whether FAPs support muscle regeneration or promote fibro-adipogenic degeneration is emerging as a key determinant in the pathogenesis of muscular diseases, including Duchenne muscular dystrophy (DMD). However, the
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全球贸易项目编号

货号GTIN
T8552-5MG04061838446640
T8552-1MG04061837379338