A0928
Aristeromycin
~95%
别名:
9-(2,3-Dihydroxy-4-[hydroxymethyl]cyclopentyl)adenine
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关于此项目
经验公式（希尔记法）:
C11H15N5O3
化学文摘社编号:
分子量:
265.27
UNSPSC Code:
51101500
PubChem Substance ID:
MDL number:
InChI
1S/C11H15N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h3-6,8-9,17-19H,1-2H2,(H2,12,13,14)/t5-,6-,8-,9+/m1/s1
SMILES string
Nc1ncnc2n(cnc12)[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O
InChI key
UGRNVLGKAGREKS-GCXDCGAKSA-N
assay
~95%
antibiotic activity spectrum
viruses
storage temp.
2-8°C
Gene Information
human ... ADORA2B(136)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Marloes P Schaddelee et al.
European journal of pharmacology, 504(1-2), 7-15 (2004-10-28)
The objective of this investigation was to characterise the pharmacokinetic-pharmacodynamic correlation of 5'-deoxy-N6-cyclopentyl-adenosine (5'dCPA) in the chronic constriction injury model of neuropathic pain. Following intravenous administration of 5'dCPA (0.30 or 0.75 mg kg(-1)), the time course of the drug concentration
Brian B Gowen et al.
PloS one, 5(9), doi:10-doi:10 (2010-09-24)
A growing number of arenaviruses can cause a devastating viral hemorrhagic fever (VHF) syndrome. They pose a public health threat as emerging viruses and because of their potential use as bioterror agents. All of the highly pathogenic New World arenaviruses
Wei Ye et al.
The Journal of organic chemistry, 71(22), 8641-8643 (2006-10-27)
The biological versatility of aristeromycin (carbocyclic adenosine) is limited by accompanying cytotoxicity caused ostensibly by the intracellular formation of its 5'-nucleotide derivatives. Aristeromycin derivatives that offered steric interference to this transformation at the C-5' center were sought. This paper describes
Fazila Zulfiqar et al.
Nucleosides, nucleotides & nucleic acids, 27(10), 1153-1157 (2008-09-13)
2-Iodonoraristeromycin, 2-iodoaristeromycin and related analogs were synthesized to investigate their inhibitory activities against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolases.
Takauki Ainai et al.
The Journal of organic chemistry, 69(3), 655-659 (2004-01-31)
Dihydroxylation of 4-aryl-1-azido-2-cyclopentenes 6, in which an aryl group is used as a synthetic equivalent of CH(2)OH, was studied to improve the low to moderate stereoselectivity previously reported for cyclopentenes 3 possessing CH(2)X and nitrogen atom-containing groups. 2-Furyl, Ph, and
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