生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
82 kDa
种属反应性
rabbit, horse, guinea pig, rat, human, bovine, dog, mouse
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SIRT1(23411)
一般描述
Sirtuin（沉默交配型信息调节2同源物）1（ 酿酒酵母）（SIRT1）是NAD（+）依赖性蛋白脱乙酰酶SIRT家族的成员，参与调节涉及能量代谢的基因的核转录。 SIRT1提供了细胞能量状态感知（NAD（+）状态）与能量稳态调节之间的联系。SIRT1参与代谢、细胞分化和衰老、应激反应和癌症的调节。
兔多克隆抗SIRT1抗体可与鸡，人，小鼠，大鼠，犬和猪的sirtuin-1酶反应。
免疫原
靶向人SIRT1 N末端区域的合成肽
应用
兔多克隆抗SIRT1抗体用于标记sirtuin-1，以通过免疫细胞化学和免疫组化（IHC）技术进行检测和定量。它被用作探针来确定sirtuin-1在核转录控制和蛋白脱乙酰化水平上NAD（+）状态依赖性能量稳态中的存在和作用。
兔抗SIRT1抗体可在0.5 μg/ml浓度下用于蛋白质印迹应用。
生化/生理作用
SIRT1是sirtuin蛋白家族的成员，与酵母Sir2蛋白同源。sirtuin家族的成员以sirtuin核心域为特征，分为四类。人类sirtuins的功能尚未确定。
外形
本品为溶于1x PBS缓冲液的纯化抗体，含 0.09% (w/v) 叠氮化钠和2%蔗糖。
其他说明
合成肽位于以下区域内： PETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKI
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
常规特殊物品
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International journal of environmental research and public health, 18(14) (2021-07-25)
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Yan Li et al.
International journal of molecular medicine, 41(6), 3517-3526 (2018-03-14)
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Mitochondrial genome maintenance plays a central role in preserving brain health. We previously demonstrated accumulation of mitochondrial DNA damage and severe neurodegeneration in transgenic mice inducibly expressing a mutated mitochondrial DNA repair enzyme (mutUNG1) selectively in forebrain neurons. Here, we
Moez Eid et al.
Frontiers in physiology, 13, 782684-782684 (2022-05-17)
Sirtuins (SIRTs) are NAD+- dependent histone deacetylases. They are involved in a variety of biological pathways and are thought to be a promising target for treating several human disorders. Although evidence is piling up to support the neuroprotective role of
Svetlana Demyanenko et al.
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Sirtuins, class III histone deacetylases, are involved in the regulation of tissue repair processes and brain functions after a stroke. The ability of some isoforms of sirtuins to circulate between the nucleus and cytoplasm may have various pathophysiological effects on
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