AV39254
Anti-GTF2IRD1 (AB3) antibody produced in rabbit
IgG fraction of antiserum
别名:
Anti-CREAM1, Anti-GTF2I repeat domain containing 1, Anti-GTF3, Anti-MUSTRD1, Anti-RBAP2, Anti-WBSCR11, Anti-WBSCR12, Anti-hMusTRD1α1
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
106 kDa
种属反应性
mouse, bovine, dog, rabbit, guinea pig, rat, human
浓度
0.5 mg - 1 mg/mL
技术
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... GTF2IRD1(9569)
一般描述
GTF2IRD1 codes for a GTF2I repeat domain containing protein. It is involved in craniofacial and cognitive development. Genetic variations in GTF2IRD1 are associated with Williams-Beuren syndrome (WBS).
Rabbit Anti-GTF2IRD1 antibody recognizes chicken, human, mouse, rat, bovine, and canine GTF2IRD1.
Rabbit Anti-GTF2IRD1 antibody recognizes chicken, human, mouse, rat, bovine, and canine GTF2IRD1.
免疫原
Synthetic peptide directed towards the C terminal region of human GTF2IRD1
应用
Rabbit Anti-GTF2IRD1 antibody is suitable for western blot (2.5 μg/ml) and IHC (4-8 μg/ml) applications.
生化/生理作用
GTF2IRD1 contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. GTF2IRD1 is related to Williams-Beuren syndrome, a multisystem developmental disorder. Western blots using three different antibodies against three unique regions of this protein target confirm the same apparent molecular weight in our tests. The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing of this gene generates at least 2 transcript variants.
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
其他说明
Synthetic peptide located within the following region: VIINQLQPFAEICNDAKVPAKDSSIPKRKRKRVSEGNSVSSSSSSSSSSS
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
E J Young et al.
Genes, brain, and behavior, 7(2), 224-234 (2007-08-08)
The GTF2IRD1 general transcription factor is a candidate for involvement in the varied cognitive and neurobehavioral symptoms of the microdeletion disorder, Williams-Beuren syndrome (WBS). We show that mice with heterozygous or homozygous disruption of Gtf2ird1 exhibit decreased fear and aggression
A Antonell et al.
Journal of medical genetics, 47(5), 312-320 (2009-11-10)
Williams-Beuren syndrome (WBS) is a developmental disorder with multisystemic manifestations mainly characterised by vascular stenoses, distinctive craniofacial features, mental retardation with a characteristic neurocognitive profile, and some endocrine and connective tissue abnormalities, caused by a recurrent deletion of 1.55 Mb
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