方案
≥98% (titration)
mp
159-160 °C (lit.)
SMILES字符串
OC(=O)Cc1ccc(cc1)-c2ccccc2
InChI
1S/C14H12O2/c15-14(16)10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-9H,10H2,(H,15,16)
InChI key
QRZAKQDHEVVFRX-UHFFFAOYSA-N
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I Smolders et al.
Antimicrobial agents and chemotherapy, 46(2), 471-477 (2002-01-18)
Fluoroquinolones are antibiotics with central excitatory side effects. These adverse effects presumably result from inhibition of gamma-aminobutyric acid (GABA) binding to GABA(A) receptors. This GABA antagonistic effect is greatly potentiated by the active metabolite of fenbufen, biphenylacetic acid (BPAA). Nevertheless
H Arima et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 6(1), 53-59 (2005-11-01)
The effect of hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) on the cutaneous penetration and activation of ethyl 4-biphenylyl acetate (EBA), a prodrug of non-steroidal anti-inflammatory drug 4-biphenylylacetic acid (BPAA), from hydrophilic ointment was investigated, using hairless mouse skin in vitro. When the hydrophilic ointment
Yohei Sakaguchi et al.
Journal of pharmaceutical and biomedical analysis, 55(1), 176-180 (2011-02-12)
Fluorous derivatization followed by fluorous-phase liquid chromatographic (LC) separation exploits the affinity between perfluoroalkyl compounds for highly selective and quantitative isolation of various analytes. However, the applicability of this technique as a simple pretreatment for fluorometric determination in clinical settings
Takako Ishiguro et al.
International journal of pharmaceutics, 419(1-2), 161-169 (2011-08-16)
2-Hydroxybutyl-β-cyclodextrins (HB-β-CyDs) with different degrees of substitution (D.S.) were prepared and their physicochemical and biological properties and solubilizing abilities were studied and compared with those of 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD). The surface activity of HB-β-CyD was higher than that of HP-β-CyD (D.S.
M Koutsoviti-Papadopoulou et al.
Pharmacological research, 44(3), 229-233 (2001-09-01)
This paper examines the effect of biphenylacetic acid on the antagonistic action of norfloxacin and enoxacin on the GABA(A)-mediated responses of the isolated guinea-pig ileum. GABA produced transient contractions followed by relaxation. The contractile effect of exogenously applied GABA was
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