生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
2D2, monoclonal
表单
buffered aqueous solution
分子量
antigen 21 kDa (and possibly a dimer of 42 kDa)
种属反应性
human, bovine
请勿与下列物质发生反应
rat, mouse
浓度
~2 mg/mL
技术
microarray: suitable
western blot: 1-5 μg/mL using cultured human breast adenocarcinoma MCF-7 cells, activated with dexamethasone
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... BAX(581)
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一般描述
Bax is a tumor suppressor that belongs to the Bcl-2 family and modulates cellular apoptosis. Bax is regulated by p53 and increased Bax levels have been associated with cell death stimuli. Alterations in Bax have been linked to several neurological diseases and cancers . Monoclonal Anti-Bax antibody is specific for the epitope within amino acids 3-16 of the human Bax protein. The antibody reacts with Bax in bovines and humans, but not in mice and rats.
免疫原
synthetic peptide corresponding to amino acids 3-16 of the human Bax sequence, conjugated to KLH.
应用
Monoclonal Anti-Bax antibody is suitable for use in western blot (1-5 μg/mL using cultured human breast adenocarcinoma MCF-7 cells, activated with dexamethasone) and microarray.
外形
Solution in phosphate bufered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics.
Carter, et al.
Blood Cancer Journal, 13, 57-57 (2023)
K G Wolter et al.
The Journal of cell biology, 139(5), 1281-1292 (1998-01-07)
Bax, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. Bax has been recently reported to be an integral membrane protein associated with organelles or bound to organelles by Bcl-2 or a soluble protein found in
Elizabeth S Henson et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(3 Pt 1), 845-853 (2006-02-10)
Monoclonal antibodies, such as herceptin and trastuzumab, against the epidermal growth factor receptor ErbB2 (also known as HER2/neu) are an effective therapy for breast cancer patients with overexpression of ErbB2. Herceptin, in combination with standard chemotherapy, such as taxol or
H J Brady et al.
The international journal of biochemistry & cell biology, 30(6), 647-650 (1998-08-08)
Bax is a pro-apoptotic member of the Bcl-2 family of genes which regulate programmed cell death. The Bax protein shares highly conserved domains with Bcl-2, some of which are required for the formation of Bax-Bcl-2 heterodimers. Bax expression is elevated
Bing Z Carter et al.
Haematologica, Online ahead of print (2020-12-24)
MCL-1 and BCL-2 are both frequently overexpressed in acute myeloid leukemia and critical for the survival of acute myeloid leukemia cells and acute myeloid leukemia stem cells. MCL-1 is a key factor in venetoclax resistance. Using genetic and pharmacological approaches
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