C239
CNQX 二钠盐 水合物
≥98% (HPLC), solid, AMPA/kainate receptor antagonist.
别名:
6-氰-7-硝基喹喔啉-2,3-二酮 二钠盐 水合物
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选择尺寸
关于此项目
经验公式（希尔记法）:
C9H2N4Na2O4 · xH2O
化学文摘社编号:
分子量:
276.12 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
CNQX 二钠盐 水合物, ≥98% (HPLC), solid
SMILES string
O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
InChI
1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2
InChI key
LCDWHGXMFAZHEO-UHFFFAOYSA-L
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
orange to red
solubility
H2O: >2 mg/mL (warmed)
Quality Level
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)
相关类别
Application
CNQX二钠盐水合物用作：
- 神经元培养物中的竞争性非NMDA受体拮抗剂和竞争性 AMPA/红藻氨酸受体拮抗剂（110）
- 谷氨酸能阻滞剂，测量投射神经元的抑制性突触后电流（111）
- AMPA谷氨酸受体拮抗剂，用于前额叶皮层神经元（112）
Biochem/physiol Actions
CNQX（6-氰基-7-硝基喹喔啉-2,3-二酮）是强效、竞争性 AMPA/红藻氨酸受体拮抗剂。它是喹喔啉衍生物，也是非N-甲基-d-天冬氨酸（非-NMDA）谷氨酸受体拮抗剂。CNQX 通过 α-氨基-3-羟基-5-甲基异恶唑-4-丙酸受体（AMPAR）介导丘脑网状核去极化。 显示出对 AMPA/红藻氨酸受体具有微摩尔亲和力。
强效、竞争性 AMPA/红藻氨酸受体拮抗剂。
Features and Benefits
这种化合物是神经科学研究的特色产品。 点击此处 ，发现更多特色神经科学产品。在 sigma.com/discover-bsm 了解更多关于其他研究领域的生物活性小分子。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Medicinal chemistry of competitive kainate receptor antagonists
Larsen, Ann M and Bunch, Lennart
ACS Chemical Neuroscience, 2(2), 60-74 (2010)
CNQX Blocks Kainate-induced Corneal Irritation
Ibitokun, Bernadette O and Miller, Kenneth E
investigate opthalmology and visual science, 53(14), 1855-1855 (2012)
Teri M Furlong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 5012-5022 (2014-04-04)
Access to highly palatable and calorically dense foods contributes to increasing rates of obesity worldwide. Some have made the controversial argument that consumption of such foods can lead to "food addiction," yet little is known about how long-term access to
Selective excitatory actions of DNQX and CNQX in rat thalamic neurons
Lee SH, et al.
Journal of Neurophysiology, 103(4), 1728-1734 (2010)
Shigehiro Namiki et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(3), 987-1001 (2013-01-18)
Correlated spiking activity prevails in immature cortical networks and is believed to contribute to neuronal circuit maturation; however, its spatiotemporal organization is not fully understood. Using wide-field calcium imaging from acute whole-brain slices of rat pups on postnatal days 1-6
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