biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
B72-H2, monoclonal
form
buffered aqueous solution
mol wt
antigen ~75 kDa
species reactivity
human
concentration
~0.5 mg/mL
technique(s)
flow cytometry: suitable, immunohistochemistry (frozen sections): suitable
isotype
IgG2a
shipped in
wet ice
Gene Information
human ... CD86(942)
General description
CD86 is one of two ligands (the other is CD80) for CD152 (CTLA-4) and CD28. CD86 acts as co-stimulatory molecule in eliciting T cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD86 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is rapidly induced on the surface of activated B cells, T cells or monocytes and is expressed at high levels on dendritic cells. It is also found on malignant Hodgkin and Reed-Sternberg (H-RS) cells in Hodgkin′s disease.
Immunogen
recombinant extracellular domain of human CD86.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 0.08% sodium azide.
Preparation Note
Prepared from tissue culture supernatant, purified using protein G.
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