D7815
R(−)-Denopamine
≥98% (HPLC), β1 adrenoceptor agonist, powder
别名:
(−)-α-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxybenzylalcohol
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关于此项目
经验公式（希尔记法）:
C18H23NO4
化学文摘社编号:
分子量:
317.38
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
R(−)-Denopamine, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 10 mg/mL, clear, H2O: insoluble
storage temp.
2-8°C
SMILES string
COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC
InChI
1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
InChI key
VHSBBVZJABQOSG-INIZCTEOSA-N
Gene Information
human ... ADRB1(153)
Application
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
Biochem/physiol Actions
Denopamine is a cardiotonic drug.
β1-adrenoceptor agonist.
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Light sensitive.
Barry M Trost et al.
Organic letters, 4(16), 2621-2623 (2002-08-03)
[reaction: see text] Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the beta-receptor agonists
Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment.
Dainari Nakajima et al.
International journal of cardiology, 108(2), 281-283 (2005-05-26)
M Hirayama et al.
Rinsho shinkeigaku = Clinical neurology, 40(8), 787-790 (2001-02-24)
In 1993, we reported the pathophysiology of postprandial hypotension (PPH) in patients with sympathetic dysfunction: a fall of BP resulted from both excess systemic vasodilation and lack of compensatory increase of cardiac output and vascular resistance in the leg arteries.
H Kurosawa et al.
Japanese journal of pharmacology, 72(4), 325-333 (1996-12-01)
Influence of cardiotonic agents on the prognosis of heart failure depends on the individual therapeutic agents, and favorable and unfavorable effects of these agents have been reported in clinical trials. We studied the effect of the cardiotonic agent denopamine on
Ruduwaan Salie et al.
Cardiovascular drugs and therapy, 25(1), 31-46 (2011-01-13)
To determine the mechanism whereby transient stimulation of the β-adrenergic receptor subtypes (β-AR) elicit cardioprotection against subsequent ischaemia. Isolated rat hearts were subjected to 35 min regional ischaemia (RI) and reperfusion and infarct size (IS) determined. Hearts were preconditioned with
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| D7815-5MG | 04061833588932 |
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