D7815
R(−)-Denopamine
≥98% (HPLC), β1 adrenoceptor agonist, powder
别名:
(−)-α-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxybenzylalcohol
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关于此项目
经验公式（希尔记法）:
C18H23NO4
化学文摘社编号:
分子量:
317.38
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
R(−)-Denopamine, ≥98% (HPLC), powder
SMILES string
COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC
InChI key
VHSBBVZJABQOSG-INIZCTEOSA-N
InChI
1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 10 mg/mL, clear
H2O: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADRB1(153)
Biochem/physiol Actions
Denopamine is a cardiotonic drug.
β1-adrenoceptor agonist.
Disclaimer
Light sensitive.
Application
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
A Distinct Role of the Autonomic Nervous System in Modulating the Function of Lymphatic Vessels under Physiological and Tumor-Draining Conditions
Bachmann SB, et al.
Testing, 27(11), 3305-3314 (2019)
S Chiba et al.
Journal of autonomic pharmacology, 21(1), 7-13 (2001-06-26)
1. Using the cannula inserting method, vasodilator responses to beta-adrenoceptor agonists (isoprenaline, denopamine and procaterol) were investigated in isolated and perfused rat common carotid arteries. 2. Each beta-adrenoceptor agonist induced a vasodilation in preparations preconstricted by phenylephrine in a dose-related
T Bando et al.
Oncology reports, 7(1), 49-52 (1999-12-22)
Cisplatin is a key drug in chemotherapy for lung cancer. It has been reported that intracellular accumulation of cisplatin is an important step as a determinant for resistance to cisplatin, which may be modulated by Na+, K+-ATPase activity. And it
Hidefumi Kaji et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(3), 403-412 (2004-12-21)
Denopamine is one of the oral beta(1)-adrenoceptor-selective partial agonists. Denopamine glucuronide is the most abundant metabolite in human, rat, and dog urine when administered orally. Species differences in denopamine glucuronidation were investigated with liver microsomes obtained from humans and experimental
A Marcantoni et al.
Pflugers Archiv : European journal of physiology, 457(5), 1093-1110 (2008-09-10)
We studied the effects of the cAMP-hydrolyzing enzyme phosphodiesterase type-4 (PDE4) on the L-type Ca(2+) channels (LTCCs) and Ca(2+)-dependent secretion in mouse chromaffin cells (MCCs). The selective PDE4 inhibitor rolipram (3 microM) had a specific potentiating action on Ca(2+) currents
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