生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
存货情况
not available in Japan
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5 μg/mL using human skeletal muscle
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... FZD3(7976)
mouse ... Fzd3(14365)
rat ... Fzd3(266715)
一般描述
FZD3 belongs to the frizzled (Fz) family. Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues (skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex). In human, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. It is expressed in several cancers (esophageal carcinoma, lung squamous cell carcinoma, primary acute and lymphoblastic leukemia, myeloma, lymphoma and Ewing sarcoma).
免疫原
synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-3, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
应用
Anti-Frizzled-3 antibody is suitable for western blot analysis. It is also suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 5μg/mL, using human skeletal muscle.
外形
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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S B Wang et al.
Genetics and molecular research : GMR, 15(1) (2016-02-26)
Frizzled 3 is an important receptor in the Wnt/β-catenin pathway, a conserved signaling pathway that regulates gene expression and controls diverse developmental processes. However, the role of this protein during follicular development in the adult ovary is not known. The
T Nohno et al.
Cellular and molecular biology (Noisy-le-Grand, France), 45(5), 653-659 (1999-10-08)
Members of the frizzled (Fz) family are involved in Wnt signaling during embryogenesis in the vertebrate. We identified chicken cognates of Fz-2, Fz-3, Fz-4, Fz-6 and Fz-8, and examined spatial and temporal expression patterns in the chick embryos by whole-mount
Yoshimi Endo et al.
Molecular and cellular biology, 28(7), 2368-2379 (2008-01-24)
Recombinant Wnt-3a stimulated the rapid formation of elongated processes in Ewing sarcoma family tumor (ESFT) cells that were identified as neurites. The processes stained positively for polymerized actin and microtubules as well as synapsin I and growth-associated protein 43. Inhibition
Sze Chuen Cesar Wong et al.
PloS one, 8(11), e79481-e79481 (2013-11-21)
Frizzled homolog 3 receptor was up-regulated in several gastrointestinal cancers such as esophageal and gastric cancers. Moreover, frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens. In the present study, we investigated the clinical significance of
商品
培养和表征CSC群体的癌症干细胞培养基、球状体培养板和癌症干细胞标志物。
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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