F3179
Anti-Frizzled-3 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-FZD3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
availability
not available in Japan
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5 μg/mL using human skeletal muscle
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FZD3(7976)
mouse ... Fzd3(14365)
rat ... Fzd3(266715)
General description
FZD3 belongs to the frizzled (Fz) family. Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues (skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex). In human, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. It is expressed in several cancers (esophageal carcinoma, lung squamous cell carcinoma, primary acute and lymphoblastic leukemia, myeloma, lymphoma and Ewing sarcoma).
Immunogen
synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-3, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
Application
Anti-Frizzled-3 antibody is suitable for western blot analysis. It is also suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 5μg/mL, using human skeletal muscle.
Physical form
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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S B Wang et al.
Genetics and molecular research : GMR, 15(1) (2016-02-26)
Frizzled 3 is an important receptor in the Wnt/β-catenin pathway, a conserved signaling pathway that regulates gene expression and controls diverse developmental processes. However, the role of this protein during follicular development in the adult ovary is not known. The
T Nohno et al.
Cellular and molecular biology (Noisy-le-Grand, France), 45(5), 653-659 (1999-10-08)
Members of the frizzled (Fz) family are involved in Wnt signaling during embryogenesis in the vertebrate. We identified chicken cognates of Fz-2, Fz-3, Fz-4, Fz-6 and Fz-8, and examined spatial and temporal expression patterns in the chick embryos by whole-mount
Yoshimi Endo et al.
Molecular and cellular biology, 28(7), 2368-2379 (2008-01-24)
Recombinant Wnt-3a stimulated the rapid formation of elongated processes in Ewing sarcoma family tumor (ESFT) cells that were identified as neurites. The processes stained positively for polymerized actin and microtubules as well as synapsin I and growth-associated protein 43. Inhibition
Sze Chuen Cesar Wong et al.
PloS one, 8(11), e79481-e79481 (2013-11-21)
Frizzled homolog 3 receptor was up-regulated in several gastrointestinal cancers such as esophageal and gastric cancers. Moreover, frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens. In the present study, we investigated the clinical significance of
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Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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