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F3627

D-果糖6-磷酸二钠盐水合物

Name: <SC>D</SC>-果糖6-磷酸 二钠盐 水合物
Brand: SIGMA

≥98%, amorphous powder

别名:

Sodium (2R,3R,4S)-2,3,4,6-tetrahydroxy-5-oxohexyl phosphate

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关于此项目

经验公式（希尔记法）:

C₆H₁₁Na₂O₉P · xH₂O

化学文摘社编号:

26177-86-6

分子量:

304.10 (anhydrous basis)

UNSPSC Code:

12352201

NACRES:

NA.25

PubChem Substance ID:

329799699

MDL number:

MFCD16661244

Beilstein/REAXYS Number:

5686786

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biological source

bacterial (Corynebacterium)

Quality Level

300

assay

≥98%

form

amorphous powder

impurities

<0.05 mol % fructose 1,6-diphosphate, <1.5 mol % glucose 6-phosphate

color

white to off-white

solubility

H₂O: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

cation traces

Na: 14.6-15.6% (dry basis)

application(s)

agriculture

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].OC[C@@]1(O)O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@@H]1O

InChI

1S/C6H13O9P.2Na.H2O/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13;;;/h3-5,7-10H,1-2H2,(H2,11,12,13);;;1H2/q;2*+1;/p-2/t3-,4-,5+,6-;;;/m1.../s1

InChI key

VSCMQICEHMPOEC-HTKRKRNRSA-L

Application

D-果糖-6-磷酸（F6P）是糖酵解途径的糖中间体，可用于帮助鉴定、区分和表征一些酶，例如磷酸果糖激酶、焦磷酸依赖性果糖-6-磷酸1-磷酸转移酶、D-果糖6-磷酸醛缩酶、谷氨酰胺：果糖-6-磷酸酰胺转移酶和葡糖胺6P合酶。

Biochem/physiol Actions

6-磷酸果糖是通过磷酸葡萄糖异构酶将6-磷酸葡萄糖异构化而产生的糖酵解中间体。

Other Notes

为了全面了解我们针对客户研究提供的各种单糖产品，建议您访问我们的碳水化合物分类页面。

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

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历史批次信息供参考:

分析证书(COA)

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Kinetic characterization of human glutamine-fructose-6-phosphate amidotransferase I: potent feedback inhibition by glucosamine 6-phosphate.

Kay O Broschat et al.

The Journal of biological chemistry, 277(17), 14764-14770 (2002-02-14)

Glutamine-fructose-6-phosphate amidotransferase (GFAT) catalyzes the first committed step in the pathway for biosynthesis of hexosamines in mammals. A member of the N-terminal nucleophile class of amidotransferases, GFAT transfers the amino group from the L-glutamine amide to D-fructose 6-phosphate, producing glutamic

Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors.

Yimin Qian et al.

Bioorganic & medicinal chemistry letters, 21(21), 6264-6269 (2011-10-01)

Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this class of compounds indicated significant impact on GFAT inhibition potency

Characterization of recombinant PPi-dependent 6-phosphofructokinases from Methylosinus trichosporium OB3b and Methylobacterium nodulans ORS 2060.

O N Rozova et al.

Biochemistry. Biokhimiia, 77(3), 288-295 (2012-07-19)

The properties of the purified recombinant PPi-dependent 6-phosphofructokinases (PPi-PFKs) from the methanotroph Methylosinus trichosporium OB3b and rhizospheric phytosymbiont Methylobacterium nodulans ORS 2060 were determined. The dependence of activities of PPi-PFK-His(6)-tag from Ms. trichosporium OB3b (6 × 45 kDa) and PPi-PFK from

Glucosamine-6-phosphate synthase--the multi-facets enzyme.

Sławomir Milewski

Biochimica et biophysica acta, 1597(2), 173-192 (2002-06-05)

L-Glutamine: D-fructose-6-phosphate amidotransferase, known under trivial name of glucosamine-6-phosphate synthase, as the only member of the amidotransferase subfamily of enzymes, does not display any ammonia-dependent activity. This enzyme, catalysing the first committed step in a pathway leading to the eventual

Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect.

Minsuh Seo et al.

PloS one, 6(9), e24179-e24179 (2011-10-01)

Cancer cells adopt glycolysis as the major source of metabolic energy production for fast cell growth. The HIF-1-induced PFKFB3 plays a key role in this adaptation by elevating the concentration of Fru-2,6-BP, the most potent glycolysis stimulator. As this metabolic

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需氧糖酵解和瓦博格效应

本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。

全球贸易项目编号

货号	GTIN
F3627-1G	04061833614310
F3627-100MG	04061833614259
F3627-5G	04061833614341
F3627-500MG	04061833614334
F3627-10MG	04061833614273

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