Anti-Glutamate Receptor 1, Metabotropic antibody produced in rabbit

synthetic peptide corresponding to the C-terminal of human metabotropic glutamate receptor 1, conjugated to KLH. The immunizing peptide has 88% homology with the rat and mouse gene.

Anti-Glutamate Receptor 1, Metabotropic antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 10μg/mL using human brain, neurons.

Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. Group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of Group I appear to have a neuroprotective effect.

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

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