H8645
(1S,9R)-(+)-β-Hydrastine
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关于此项目
经验公式（希尔记法）:
C21H21NO6
化学文摘社编号:
分子量:
383.39
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
storage temp.
−20°C
SMILES string
[H][C@]1(OC(=O)c2c(OC)c(OC)ccc12)[C@@]3([H])N(C)CCc4cc5OCOc5cc34
InChI
1S/C21H21NO6/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3/t18-,19+/m0/s1
InChI key
JZUTXVTYJDCMDU-RBUKOAKNSA-N
Gene Information
Biochem/physiol Actions
Potent competitive GABAA receptor antagonist which is more potent than bicuculline; isolated from Corydalis stricta.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J H Huang et al.
British journal of pharmacology, 99(4), 727-730 (1990-04-01)
1. (+)-Hydrastine is a phthalide isoquinoline alkaloid, isolated from Corydalis stricta. It has the same 1S,9R configuration as the competitive GABAA receptor antagonist bicuculline and is the enantiomer of the commercially available (-)-hydrastine. 2. (+)-Hydrastine (CD50 0.16 mg kg-1, i.v.)
J J Inbaraj et al.
Chemical research in toxicology, 19(6), 739-744 (2006-06-20)
Goldenseal is an herb that is widely used in dietary supplements, eye washes, and skin lotions. The presence of Goldenseal root powder in dietary supplements and the topical application of Goldenseal preparations raise the possibility that an adverse phototoxic reaction
David J Edwards et al.
Journal of the American Pharmacists Association : JAPhA, 43(3), 419-423 (2003-07-03)
To determine the concentration of hydrastine and berberine, the primary alkaloids in herbal products containing goldenseal. Descriptive comparison of 20 products purchased at local pharmacies or health food stores; 17 products were labeled as containing goldenseal root and 3 products