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Merck
CN

I119

Indatraline hydrochloride

monoamine transport inhibitor, solid

别名:

(±)-trans-3-(3,4-Dichlorophenyl)-N-methyl-1-indanamine hydrochloride, Lu 19-005

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关于此项目

经验公式（希尔记法）:
C16H15Cl2N · HCl
化学文摘社编号:
96850-13-4
分子量:
328.66
UNSPSC Code:
12352200
PubChem Substance ID:
24277939
NACRES:
NA.77
MDL number:
MFCD00083178

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产品名称

Indatraline hydrochloride, solid

SMILES string

Cl.CN[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13

InChI

1S/C16H15Cl2N.ClH/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10;/h2-8,13,16,19H,9H2,1H3;1H/t13-,16+;/m0./s1

InChI key

QICQDZXGZOVTEF-MELYUZJYSA-N

form

solid

color

white

solubility

H2O: 2 mg/mL

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

相关类别

Application

Indatraline hydrochloride has been used:
  • as a competitive inhibitor of 3H-dopamine ([3H]DA) to study its effects on trans-activator of transcription (Tat) protein on cocaine-induced inhibition of uptake of [3H]DA
  • as a dopamine transport blocker to study its effects on trace amine-associated receptor 1 (TAAR1)-transfected mice cells
  • as a nonselective monoamine transport inhibitor to study its anti-angiogenic activities in glioblastoma multiforme (GBM)

Biochem/physiol Actions

Indatraline is a non-selective monoamine transport inhibitor. It inhibits the reuptake of neurotransmitters, such as serotonin, norepinephrine and dopamine. It exhibits anti-depressant and anti-angiogenic effects. Indatraline also plays a role in inducing autophagy.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with the permission of H. Lundbeck A/S.

pictograms

Environment
GHS09

signalword

Warning

hcodes

H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000364141
0000364141
0000262455
0000262455
0000013557

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M Laruelle et al.
Synapse (New York, N.Y.), 13(4), 295-309 (1993-04-01)
Single photon emission computed tomography (SPECT) studies of regional kinetic uptake and pharmacological specificity of [123I]methyl 3 beta-(4-iodophenyl) tropane-2 beta-carboxylate ([123I]beta-CIT) were performed in nonhuman primates (n = 41). In control experiments, activity was concentrated in striatum and in hypothalamic/midbrain
Y L Hurd et al.
Life sciences, 45(4), 283-293 (1989-01-01)
In vivo microdialysis was utilized to evaluate the role of extracellular Na+ in regulating dopamine (DA) neurotransmission in the caudate-putamen of halothane-anaesthetized rats. Reduction of the extracellular Na+ concentration by introduction of a perfusion media containing 50mM Na+ (with choline
Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice
Panas H N, et al.
Journal of Neuroscience Research, 88(9), 1962-1969 (2010)
K Stengård
Pharmacology & toxicology, 75(2), 115-118 (1994-08-01)
Intracerebral microdialysis was performed on awake, freely moving rats in order to record effect of toluene exposure on acetylcholine release in striatum. Acetylcholine release decreased during (about 20%) and after (about 60%) toluene exposure (2 hr, 2000 p.p.m.) Striatal acetylcholine
S S Negus et al.
The Journal of pharmacology and experimental therapeutics, 291(1), 60-69 (1999-09-22)
Cocaine is a nonselective monoamine reuptake inhibitor that is widely abused. Useful pharmacotherapies for cocaine dependence may include substitution medications that produce cocaine-like effects but have a slower onset and longer duration of action. Accordingly, the present study examined the
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