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Merck
CN

I9279

Sigma-Aldrich

Interleukin-11 from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

别名:

IL-11

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关于此项目

MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.32
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生物来源

mouse

质量水平

重组

expressed in E. coli

方案

>97% (SDS-PAGE)

表单

lyophilized powder

分子量

predicted mol wt ~19 kDa

包装

pkg of 5 μg

杂质

endotoxin, tested

UniProt登记号

储存温度

−20°C

基因信息

mouse ... Il11(16156)

生化/生理作用

Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.

外形

Lyophilized from a 20.0 μL of a 0.2 μm filtered solution in phosphate buffered saline, pH 7.3, with 5% trehalose and with 50 μg bovine serum albumin per 1μg as a carrier protein.

分析说明

Assayed in a cell proliferation assay using T11 cells, a subline of the IL-6 dependent mouse plasmacytoma cell line T1165.85.2, that has been adapted to grow in IL-11.

储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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J C Morris et al.
Experimental hematology, 24(12), 1369-1376 (1996-10-01)
Human interleukin-11 (IL-11) has been shown to have pleiotropic action on hematopoietic, hepatic, stromal, epithelial, neural, and osteoclast cells. In the present work, the murine IL-11 cDNA has been isolated from a fetal thymic cell line, and its structure and
Samadhi Aparicio-Siegmund et al.
Oncotarget, 5(8), 2131-2148 (2014-04-20)
The Janus kinase / signal transducer and activator of transcription (Jak/STAT) pathway can be activated by many different cytokines, among them all members of the Interleukin (IL-)6 family. Dysregulation of this pathway, resulting in its constitutive activation, is associated with
Brandon K Hadland et al.
The Journal of clinical investigation, 125(5), 2032-2045 (2015-04-14)
Hematopoietic stem cells (HSCs) first emerge during embryonic development within vessels such as the dorsal aorta of the aorta-gonad-mesonephros (AGM) region, suggesting that signals from the vascular microenvironment are critical for HSC development. Here, we demonstrated that AGM-derived endothelial cells

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