M5560
(S)-2-氨基-2-甲基-4-膦酰基丁酸 盐酸盐
synthetic, solid
别名:
(S)-MAP4 hydrochloride
生物来源
synthetic
质量水平
表单
solid
颜色
white
SMILES字符串
Cl.C[C@](N)(CCP(O)(O)=O)C(O)=O
InChI
1S/C5H12NO5P.ClH/c1-5(6,4(7)8)2-3-12(9,10)11;/h2-3,6H2,1H3,(H,7,8)(H2,9,10,11);1H/t5-;/m0./s1
InChI key
DNFXUQUECNSSJF-JEDNCBNOSA-N
基因信息
human ... GRM4(2914), GRM6(2916), GRM7(2917)
生化/生理作用
Selective mGluR4,6,7 metabotropic glutamate receptor antagonist.
特点和优势
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
T E Salt et al.
Neuroscience, 65(1), 5-13 (1995-03-01)
A variety of metabotropic excitatory amino acid receptors are present in the thalamus. We have investigated the possibility that some of these receptors may have presynaptic effects on GABAergic inhibitory transmission in the thalamus. Inhibitory responses in ventrobasal thalamic neurons
T Knöpfel et al.
Neuropharmacology, 34(8), 1099-1102 (1995-08-01)
The two reported metabotropic glutamate receptor (mGluR) antagonists, alpha-methyl-cyclopropyl glycine (MCCG) and alpha-methyl-aminophosphonobutyrate (MAP4) were tested on the mGluR1b, mGluR2 and mGluR4a subtypes of human mGluRs. Neither MCCG (500 microM) nor MAP4 (500 microM) antagonized the activation of mGluR1b by
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