M7556
Anti-MAP Kinase 2 (ERK-2) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution, ~1 mg/mL
别名:
Anti-ERK-2
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 42 kDa
种属反应性
rat, human, mouse
浓度
~1 mg/mL
技术
immunoprecipitation (IP): 5 μg using 0.5-1 mg of a mouse 3T3 fibroblast lysate
western blot: 0.5-2 μg/mL using human A431 cells, mouse 3T3 fibroblasts or rat L6 cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MAPK1(5594)
mouse ... Ephb2(13844), Mapk1(26413)
rat ... Mapk1(116590)
一般描述
Mitogen-activated protein kinases (MAPKs) regulate a wide range of functions by modulating cellular signal transduction. These functions include cellular growth, differentiation, movement and apoptosis. Conventional MAPKs comprise of the ERK1/2, p38, JNK and ERK5 kinase families. ERK1 and ERK2 are highly conserved serine/threonine kinases that are responsive to growth factors
Anti-MAP Kinase 2 (ERK-2) antibody is specific for MAPK2 (42 kDa) in mice, humans and rats. This antibody does not cross react with MAP kinase 1 (ERK-1) nor does it interfere with the kinase activity.
Anti-MAP Kinase 2 (ERK-2) antibody is specific for MAPK2 (42 kDa) in mice, humans and rats. This antibody does not cross react with MAP kinase 1 (ERK-1) nor does it interfere with the kinase activity.
免疫原
recombinant mouse MAP Kinase 2 (MAPK2, ERK-2).
应用
Anti-MAP Kinase 2 (ERK-2) antibody is suitable for use in western blot (0.5-2 μg/mL using human A431 cells, mouse 3T3 fibroblasts or rat L6 cells). The product can also be used for immunoprecipitation (5 μg, using 0.5-1 mg of a mouse 3T3 fibroblast lysate).
外形
Solution in 0.02 M phosphate buffer, pH 7.6, 0.25 M NaCl, and ≤ 0.1% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
H Owaki et al.
Biochemical and biophysical research communications, 182(3), 1416-1422 (1992-02-14)
Extracellular signal-regulated kinases 1 and 2 are growth factor-sensitive serine/threonine kinases. cDNAs for both human kinases were isolated and sequenced. The nucleic acid and deduced protein sequences of human extracellular signal-regulated kinase 1 were 88% and 96% identical, respectively, to
Yusaku Miyamae et al.
Cell chemical biology, 27(12), 1573-1581 (2020-10-03)
Here, we report a method to regulate cellular protein levels by introducing a ubiquitin variant between a destabilizing domain (DD) and the regulated protein. When produced in the absence of a stabilizing ligand the DD dominates and the entire fusion
Marie Cargnello et al.
Microbiology and molecular biology reviews : MMBR, 75(1), 50-83 (2011-03-05)
The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by relaying extracellular signals to intracellular responses. In mammals, there are more than a dozen MAPK enzymes that coordinately regulate cell proliferation, differentiation, motility, and survival. The best known are the
Yunjie Zhang et al.
Oncology letters, 15(4), 5620-5626 (2018-03-20)
The present study assessed the mechanism underlying the effect of sorafenib on the proliferation and apoptosis of the acute promyelocytic leukemia (APL) cell line NB4. NB4 cells were treated with different concentrations of sorafenib (0, 1.5, 3, 6, and 12
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