M7642
4-马来酰亚胺基丁酸 N -羟基琥珀酰亚胺酯
powder
别名:
4-马来酰亚胺基丁酸 N -琥珀酰亚胺酯, N -琥珀酰亚胺基 4-马来酰亚胺基丁酸酯, N-(γ-马来酰亚胺丁酰氧基)琥珀酰亚胺, GMBS
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关于此项目
经验公式（希尔记法）:
C12H12N2O6
化学文摘社编号:
分子量:
280.23
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
6427689
MDL number:
form
powder
solubility
chloroform: 100 mg/mL, DMF: soluble
storage temp.
2-8°C
SMILES string
O=C1N(CCCC(ON2C(CCC2=O)=O)=O)C(C=C1)=O
InChI
1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2
InChI key
PVGATNRYUYNBHO-UHFFFAOYSA-N
Application
一种具有胺和巯基反应性的异双功能交联剂。通常，最初通过在 pH 7.5 (6.5-8.5) 下缓冲的酰胺键与含有伯胺的分子偶联。通过硫醚键在 pH 6.8 (6.5-7.0) 下缓冲的含游离巯基的分子的特异性二次偶联。用于制备酶免疫结合物和半抗原载体分子结合物。提供 7 原子链接器。
法规信息
新产品
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Parjit Kaur et al.
Biochemistry, 44(7), 2661-2670 (2005-02-16)
DrrA and DrrB proteins confer resistance to the commonly used anticancer agents daunorubicin and doxorubicin in the producer organism Streptomyces peucetius. The drrAB locus has previously been cloned in Escherichia coli, and the proteins have been found to be functional
Xiaoying Xue et al.
Biomacromolecules, 14(2), 331-341 (2013-01-11)
PEGylation can improve the protein efficacy by prolonging serum half-life and reducing proteolytic sensitivity and immunogenicity. However, PEGylation may decrease the bioactivity of a protein by interfering with binding of its substrate or receptors. Here, staphylokinase (SAK), a thrombolysis agent
Lolke De Haan et al.
Infection and immunity, 70(6), 3249-3258 (2002-05-16)
Current immunization strategies, using peptide or protein antigens, generally fail to elicit cytotoxic-T-lymphocyte responses, since these antigens are unable to access intracellular compartments where loading of major histocompatibility complex class I (MHC-I) molecules occurs. In an attempt to circumvent this