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Merck
CN

M8777

Sigma-Aldrich

吗啡 硫酸盐 五水合物

μ opioid receptor agonist, powder

别名:

吗啡五水硫酸盐

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关于此项目

经验公式（希尔记法）:
C34H40N2O10S · 5H2O
CAS Number:
6211-15-0
分子量:
758.83
MDL编号:
MFCD00150902
UNSPSC代码:
12352210
PubChem化学物质编号:
329818069
NACRES:
NA.77

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Product Name

吗啡 硫酸盐 五水合物,

表单

powder

质量水平

200

药品控制

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

溶解性

ethanol: 1.8 mg/mL
H2O: 64 mg/mL

创始人

Baxter

SMILES字符串

O.O.O.O.O.OS(O)(=O)=O.CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35.CN6CC[C@]78[C@H]9Oc%10c(O)ccc(C[C@@H]6[C@@H]7C=C[C@@H]9O)c8%10

InChI

1S/2C17H19NO3.H2O4S.5H2O/c2*1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4;;;;;/h2*2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4);5*1H2/t2*10-,11+,13-,16-,17-;;;;;;/m00....../s1

InChI key

GRVOTVYEFDAHCL-RTSZDRIGSA-N

基因信息

human ... OPRM1(4988)

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相关类别

生化/生理作用

Narcotic analgesic; prototypic μ opioid receptor agonist; also agonist at κ opioid receptors.

特点和优势

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302,H336

危险分类

Acute Tox. 4 Oral - STOT SE 3

靶器官

Central nervous system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000474470
0000474469
0000474468
0000474469
0000474468

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L Stanasila et al.
Journal of neurochemistry, 75(3), 1190-1199 (2000-08-11)
Two constructs encoding the human micro-opioid receptor (hMOR) fused at its C terminus to either one of two Galpha subunits, Galpha(o1) (hMOR-Galpha(o1)) and Galpha(i2) (hMOR-Galpha(i2)), were expressed in Escherichia coli at levels suitable for pharmacological studies (0.4-0.5 pmol/mg). Receptors fused
S Katsumata et al.
European journal of pharmacology, 291(3), 367-373 (1995-11-30)
We investigated the binding characteristics of dihydroetorphine, 7,8-dihydro-7 alpha-[1-(R)-hydroxy-1-methylbutyl]-6, 14-endoethanotetrahydro-oripavine, and its effect on the inhibitory system of cyclic AMP production using cloned mu-, delta- and kappa-opioid receptors expressed on Chinese hamster ovary cells. The Ki values of dihydroetorphine for
Stuti Agarwal et al.
American journal of physiology. Lung cellular and molecular physiology, 318(5), L1097-L1108 (2020-04-03)
We previously demonstrated that the combined exposure of human pulmonary microvascular endothelial cells (HPMECs) to morphine and viral protein(s) results in the oxidative stress-mediated induction of autophagy, leading to shift in the cells from early apoptotic to apoptosis-resistant proliferative status
G Martin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(20), 9081-9089 (1999-10-12)
In a study of a possible substrate underlying morphine addiction, we examined NMDA receptor-mediated synaptic transmission of core nucleus accumbens neurons after chronic morphine treatment, using intracellular recording in a slice preparation of rat. We evoked pharmacologically isolated NMDA EPSCs
Lori N Eidson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(40), 15952-15963 (2013-10-04)
The ventrolateral periaqueductal gray (vlPAG) is an integral locus for morphine action. Although it is clear that glia contribute to the development of morphine tolerance, to date, the investigation of their role has been limited to spinal and medullary loci.
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