P1985
Platelet-Derived Growth Factor Soluble Receptor α human
>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
别名:
PDGF sRα
biological source
human
recombinant
expressed in NSO cells
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
5-10 μg/mL ED50
mol wt
predicted mol wt ~56 kDa
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... PDGFRA(5156)
Biochem/physiol Actions
Member of the class III subfamily of receptor tyrosine kinases; binds all three PDGF isoforms with high affinity and induces receptor homo-and heterodimerization and signal transduction.
Recombinant human platelet-derived growth factor soluble receptor α, a member of the class III subfamily of receptor tyrosine kinases, binds all three PDGF isoforms with high affinity and induces receptor homo-and heterodimerization and signal transduction.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin
Analysis Note
The bioactivity is measured by its ability to inhibit human PDGF-AB or recombinant human PDGF-AA in quiescent NR6R-3T3 fibroblasts.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Heldin, C.H., et al. et al.
Guidebook to Cytokines and Their Receptors, 202-202 (1994)
L Claesson-Welsh et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(13), 4917-4921 (1989-07-01)
The primary structure of the human A-type receptor for platelet-derived growth factor (PDGF) has been determined. A 6.5-kilobase (kb) transcript was identified through low-stringency hybridization with a probe derived from the B-type PDGF receptor cDNA. The sequence of a cDNA
Purification of human platelet-derived growth factor.
E W Raines et al.
Methods in enzymology, 109, 749-773 (1985-01-01)
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