R5648
咖马林
别名:
1-[6-[（3-乙酰基-2,4,6-三羟基-5-甲基苯基）甲基]-5,7-二羟基-2,2-二甲基-2H-1-苯并吡喃-8-基]-3-苯基-2-丙烯-1-酮, 菲律宾野桐毒素
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关于此项目
经验公式（希尔记法）:
C30H28O8
化学文摘社编号:
分子量:
516.54
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
201-395-4
MDL number:
InChI key
DEZFNHCVIZBHBI-ZHACJKMWSA-N
InChI
1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
SMILES string
CC(=O)c1c(O)c(C)c(O)c(Cc2c(O)c3C=CC(C)(C)Oc3c(c2O)C(=O)\C=C\c4ccccc4)c1O
biological source
plant (Mallotus philippinensis)
assay
≥95% (HPLC)
form
powder
mp
200.0 °C
solubility
ethanol: 1 mg/mL
storage temp.
2-8°C
Gene Information
human ... CDK2(1017)
General description
粗糠柴毒素从粗糠柴（ Mallotus philippinensis）中提取。是蛋白激酶 Cδ （PKCδ）抑制剂。粗糠柴毒素作为解偶联剂，将线粒体进行的呼吸作用与氧化磷酸化解偶联。具有抗肿瘤、自噬、抗增殖、抗转移和抗侵袭特性。
Application
粗糠柴毒素用于：
- 作为蛋白激酶 C δ (PKCδ) 抑制剂，分析大鼠体内蛋白含量和磷酸化情况
- 检查早期成骨细胞标记物的基因表达
- 通过琥珀酸，减弱丙酮酸脱氢酶（PDH）的磷酸化作用
- 使线粒体去极化
- 研究其在胰腺癌细胞（Pc）中的抗肿瘤活性
Biochem/physiol Actions
大电导电压的有效激活剂和 Ca2+ 激活 K + 通道；hERG 通道激活剂。
最近，粗糠紫毒素已被证明是大电导电压和 Ca2 激活 K+通道的有效激活剂，并可使通道的电导-电压关系向左偏移。在 hERG 通道上测试的粗糠紫毒素通过左移 hERG 激活的电压依赖性和减缓通道失活，增加了阶跃和尾部 hERG 电流。这些作用将粗糠紫毒素区分为一种新型天然存在的 hERG 通道激活剂。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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