S0193
SKF-86002
≥98% (HPLC), solid
别名:
6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole
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关于此项目
经验公式（希尔记法）:
C16H12N3FS
化学文摘社编号:
分子量:
297.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
SKF-86002, ≥98% (HPLC), solid
InChI
1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
SMILES string
Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4
InChI key
YOELZIQOLWZLQC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
off-white
mp
189-190 °C (lit.)
solubility
DMSO: soluble >10 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... IL1B(3553), TNF(7124)
rat ... Alox5(25290)
Biochem/physiol Actions
p38 MAP kinase inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
M Pouliot et al.
Journal of immunology (Baltimore, Md. : 1950), 158(10), 4930-4937 (1997-05-15)
Prostaglandin endoperoxide synthase (PGHS; cyclooxygenase), the rate-limiting enzyme in the conversion of arachidonic acid to prostanoids, has two isoforms. PGHS-1 is constitutively expressed and involved in homeostasis, whereas PGHS-2 is inducible in monocytes in response to proinflammatory agents. Using freshly
Maria Tsirigotis et al.
PloS one, 3(5), e2130-e2130 (2008-05-08)
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood. Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p38MAPK and that the atypical PKC iota
M Kusuhara et al.
Circulation research, 83(8), 824-831 (1998-10-20)
Activation of the Na+/H+ exchanger isoform-1 (NHE-1) by angiotensin II is an early signal transduction event that may regulate vascular smooth muscle cell (VSMC) growth and migration. Many signal transduction events stimulated by angiotensin II are mediated by the mitogen-activated
A Sodhi et al.
Cancer research, 60(17), 4873-4880 (2000-09-15)
The elucidation of the molecular mechanisms governing the transition from a nonangiogenic to an angiogenic phenotype is central for understanding and controlling malignancies. Viral oncogenes represent powerful tools for disclosing transforming mechanisms, and they may also afford the possibility of
David J Diller et al.
Current topics in medicinal chemistry, 5(10), 953-965 (2005-09-24)
In the late 1970s and the early 1980s the initial p38 chemotype, the triaryl imidazoles, was discovered as an off-target effect during the development of cyclooxygenase and 5-lipoxygenase inhibitors long before the identity of the p38 kinase was known. During
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