S0193
SKF-86002
≥98% (HPLC), solid
别名:
6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole
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关于此项目
经验公式（希尔记法）:
C16H12N3FS
化学文摘社编号:
分子量:
297.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
SKF-86002, ≥98% (HPLC), solid
InChI
1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
SMILES string
Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4
InChI key
YOELZIQOLWZLQC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
off-white
mp
189-190 °C (lit.)
solubility
DMSO: soluble >10 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... IL1B(3553), TNF(7124)
rat ... Alox5(25290)
Biochem/physiol Actions
p38 MAP kinase inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
M Kusuhara et al.
Circulation research, 83(8), 824-831 (1998-10-20)
Activation of the Na+/H+ exchanger isoform-1 (NHE-1) by angiotensin II is an early signal transduction event that may regulate vascular smooth muscle cell (VSMC) growth and migration. Many signal transduction events stimulated by angiotensin II are mediated by the mitogen-activated
B Schnyder et al.
The Biochemical journal, 331 ( Pt 2), 489-495 (1998-06-11)
Intracellular phosphorylations polymorphonuclear neutrophils are mediated by kinases, including mitogen activated-protein (MAP) kinases and phosphatidylinositol 3-kinase. In the present study we demonstrate their effector functions upon both ligation of cell-surface seven-transmembrane-spanning receptors by bacterial peptide formylmethionyl-leucylphenylalanine as well as in
A Sodhi et al.
Cancer research, 60(17), 4873-4880 (2000-09-15)
The elucidation of the molecular mechanisms governing the transition from a nonangiogenic to an angiogenic phenotype is central for understanding and controlling malignancies. Viral oncogenes represent powerful tools for disclosing transforming mechanisms, and they may also afford the possibility of
David J Diller et al.
Current topics in medicinal chemistry, 5(10), 953-965 (2005-09-24)
In the late 1970s and the early 1980s the initial p38 chemotype, the triaryl imidazoles, was discovered as an off-target effect during the development of cyclooxygenase and 5-lipoxygenase inhibitors long before the identity of the p38 kinase was known. During
Javier Hernández Losa et al.
Oncogene, 22(26), 3998-4006 (2003-06-25)
p38 MAPK has been implicated in the response to cancer therapy. To determine whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the activation of p38 MAPK in response to several chemotherapeutic agents, such as
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