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S0193

SKF-86002

Name: SKF-86002
Brand: SIGMA

≥98% (HPLC), solid

别名:

6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₂N₃FS

化学文摘社编号:

72873-74-6

分子量:

297.35

NACRES:

NA.77

PubChem Substance ID:

24724598

UNSPSC Code:

12352200

MDL number:

MFCD00869367

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

off-white

mp

189-190 °C (lit.)

solubility

DMSO: soluble >10 mg/mL

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4

InChI

1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

InChI key

YOELZIQOLWZLQC-UHFFFAOYSA-N

Gene Information

human ... IL1B(3553), TNF(7124)
rat ... Alox5(25290)

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Biochem/physiol Actions

p38 MAP kinase inhibitor.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.

M Pouliot et al.

Journal of immunology (Baltimore, Md. : 1950), 158(10), 4930-4937 (1997-05-15)

Prostaglandin endoperoxide synthase (PGHS; cyclooxygenase), the rate-limiting enzyme in the conversion of arachidonic acid to prostanoids, has two isoforms. PGHS-1 is constitutively expressed and involved in homeostasis, whereas PGHS-2 is inducible in monocytes in response to proinflammatory agents. Using freshly

Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.

Maria Tsirigotis et al.

PloS one, 3(5), e2130-e2130 (2008-05-08)

The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood. Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p38MAPK and that the atypical PKC iota

Mast cell tumor necrosis factor alpha production is regulated by MEK kinases.

T Ishizuka et al.

Proceedings of the National Academy of Sciences of the United States of America, 94(12), 6358-6363 (1997-06-10)

Mast cells synthesize and secrete specific cytokines and chemokines which play an important role in allergic inflammation. Aggregation of the high-affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) in MC/9 mouse mast cells stimulates the synthesis and secretion of tumor

Small molecular anti-cytokine agents.

Gerd Wagner et al.

Medicinal research reviews, 26(1), 1-62 (2005-11-12)

The recent successful introduction of the anti-cytokine biologicals Etanercept, Infliximab, Adalimumab, and Anakinra has stimulated the search for anti-cytokine small-molecules. A number of molecular targets have been identified for the development of such small molecular anti-cytokine agents. The focus of

Inhibition of p38 MAP kinase as a therapeutic strategy.

J C Lee et al.

Immunopharmacology, 47(2-3), 185-201 (2000-07-06)

Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has progressed dramatically. The key advances include (1) identification of p38 MAP kinase homologs and protein kinases that act upstream and downstream from p38 MAP kinase

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全球贸易项目编号

货号	GTIN
S0193-5MG	04061832449654

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