S0193
SKF-86002
≥98% (HPLC), solid
别名:
6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole
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关于此项目
经验公式（希尔记法）:
C16H12N3FS
化学文摘社编号:
分子量:
297.35
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
off-white
mp
189-190 °C (lit.)
溶解性
DMSO: soluble >10 mg/mL
储存温度
2-8°C
SMILES字符串
Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4
InChI
1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
InChI key
YOELZIQOLWZLQC-UHFFFAOYSA-N
基因信息
human ... IL1B(3553), TNF(7124)
rat ... Alox5(25290)
相关类别
生化/生理作用
p38 MAP kinase inhibitor.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
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Toxicological sciences : an official journal of the Society of Toxicology, 68(1), 82-92 (2002-06-21)
Various forms of inorganic arsenic are significant environmental contaminants that have multiple effects on cells, including the induction of apoptotic cell death. Induction of apoptosis in lymphoid cells can mediate immunotoxicity following exposure to chemicals. However, the mechanisms regulating the
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PloS one, 3(5), e2130-e2130 (2008-05-08)
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood. Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p38MAPK and that the atypical PKC iota
M Pouliot et al.
Journal of immunology (Baltimore, Md. : 1950), 158(10), 4930-4937 (1997-05-15)
Prostaglandin endoperoxide synthase (PGHS; cyclooxygenase), the rate-limiting enzyme in the conversion of arachidonic acid to prostanoids, has two isoforms. PGHS-1 is constitutively expressed and involved in homeostasis, whereas PGHS-2 is inducible in monocytes in response to proinflammatory agents. Using freshly
M Kusuhara et al.
Circulation research, 83(8), 824-831 (1998-10-20)
Activation of the Na+/H+ exchanger isoform-1 (NHE-1) by angiotensin II is an early signal transduction event that may regulate vascular smooth muscle cell (VSMC) growth and migration. Many signal transduction events stimulated by angiotensin II are mediated by the mitogen-activated
Javier Hernández Losa et al.
Oncogene, 22(26), 3998-4006 (2003-06-25)
p38 MAPK has been implicated in the response to cancer therapy. To determine whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the activation of p38 MAPK in response to several chemotherapeutic agents, such as
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