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S5321

S15535

Name: S15535
Brand: SIGMA

≥98% (HPLC), solid

别名:

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₄N₂O₂

化学文摘社编号:

146998-34-7

分子量:

336.43

NACRES:

NA.77

PubChem Substance ID:

329824452

UNSPSC Code:

12352200

MDL number:

MFCD00911672

Assay:

≥98% (HPLC)

Form:

solid

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属性

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~6 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

C1COc2c(O1)cccc2N3CCN(CC3)C4Cc5ccccc5C4

InChI

1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2

InChI key

QJPPEMXOOWNICQ-UHFFFAOYSA-N

说明

Application

S15535 has been used as a serotonin 1A receptor (5-HT1A) agonist in zebrafish.

S15535 may be used in histamine 5-HT_1A-medaited cell signaling studies.

Biochem/physiol Actions

Potent, orally active, partial 5-HT_1A receptor agonist

S15535, a benzodioxane, is a selective but partial agonist of histamine serotonin 1A (5-HT_1A) receptor. It activates presynaptic 5-HT_1A receptors and suppresses the release of hippocampal 5-HT. It acts as an anxiolytic agent and modulates the cholinergic and cognitive function in rodents.

pictograms

GHS09

signalword

Warning

hcodes

H410

pcodes

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c