mp
177 °C (dec.) (lit.)
SMILES字符串
ONC(=O)c1ccccc1O
InChI
1S/C7H7NO3/c9-6-4-2-1-3-5(6)7(10)8-11/h1-4,9,11H,(H,8,10)
InChI key
HBROZNQEVUILML-UHFFFAOYSA-N
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Prasenjit Mukherjee et al.
Bioorganic & medicinal chemistry, 16(9), 5254-5265 (2008-03-26)
The histone deacetylase (HDAC) enzyme from Plasmodium falciparum has been identified as a novel target for the development of antimalarial therapy. A ligand-refined homology model of PfHDAC-1 was generated from the crystal structures of human HDAC8 and HDLP using a
Charlotte A Lanteri et al.
Antimicrobial agents and chemotherapy, 52(3), 875-882 (2007-12-19)
Human African trypanosomiasis (HAT) is a fatal tropical disease caused by infection with protozoans of the species Trypanosoma brucei gambiense and T. b. rhodesiense. An oral prodrug, DB289, is a promising new therapy undergoing phase III clinical trials for early-stage
Benoît M R Liénard et al.
Bioorganic & medicinal chemistry letters, 17(4), 964-968 (2006-12-13)
Metallo-beta-lactamases (MBLs) catalyze the hydrolysis of beta-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K(i) of
David J Merkler et al.
Bioorganic & medicinal chemistry, 16(23), 10061-10074 (2008-10-28)
Peptidyl alpha-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of alpha-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease and as insecticides for
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