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About This Item
经验公式（希尔记法）:
C12H11N3O
CAS Number:
分子量:
213.24
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
方案
≥99% (HPLC)
表单
crystalline
颜色
red
SMILES字符串
Cc1ccc(O)c(\N=N\c2ccccc2)n1
InChI
1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+
InChI key
LOCPVWIREQIGNQ-CCEZHUSRSA-N
基因信息
human ... GRM1(2911), GRM5(2915)
应用
SIB 1757 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.
生化/生理作用
SIB 1757 is a highly selective mGluR5 metabotropic glutamate receptor antagonist. It non-competitively inhibits glutamate-induced increase in Ca2+ at human metabotropic glutamate receptor 1 (hmGluR1).1 Inhibition of mGlu5 receptor renders protection to neurons2 against methamphetamine-induced oxidative damage.3
特点和优势
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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