SAB2500452
Anti-GATA1 antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-ERYF1, Anti-GF1, Anti-HGNC:4170, Anti-NFE1
产品名称
Anti-GATA1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, canine, mouse, rat
technique(s)
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GATA1(2623)
Biochem/physiol Actions
GATA binding protein 1 (GATA1) plays a crucial role in erythroid and megakaryocyte differentiation and proliferation. It modulates the expression of genes and acts as an E-cadherin repressor. Mutations in the GATA1 gene have been linked to transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). The protein has anti-apoptotic functions in breast cancer.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
GATA binding protein 1 (GATA1) is a key hematopoietic transcription factor. It is part of the GATA transcription factor family and the gene encoding it is localized on human chromosome Xp11.23.
Immunogen
Peptide with sequence C-DAEAYRHSPVFQ from the internal region of the protein sequence according to NP_002040.1.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling.
Li Y
Oncotarget (2015)
GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder.
Lum SH
Singapore Medical Journal, 57(6), 320-324 (2016)
Leif S Ludwig et al.
Cell reports, 27(11), 3228-3240 (2019-06-13)
Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This process is also of considerable interest for better understanding anemias and identifying new therapies. Here, we apply deep transcriptomic and accessible chromatin profiling to characterize a faithful ex vivo human erythroid
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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