biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
human, mouse
technique(s)
immunohistochemistry: 1: 20-100, western blot: 1:200-1:1000
accession no.
NP_054862
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CD274(29126)
General description
程序性细胞死亡1配体1（PD-L1），又称分化簇（CD274）或B7同源物1（B7-H1），是不断增长的B7免疫分子家族的成员。PD-L1是一种细胞表面免疫球蛋白，胞外区有两个Ig样结构域和一个短胞质结构域。该蛋白在心脏、骨骼肌、胎盘和肺中高表达，在胸腺、脾脏、肾脏和肝脏中弱表达。PD-L1在活化的T细胞、B细胞、树突状细胞、角质形成细胞和单核细胞上表达。编码它的基因位于人类染色体9p24.1。
Immunogen
人 CD274 的合成肽
Biochem/physiol Actions
程序性细胞死亡1配体1（PD-L1）参与细胞和体液免疫反应的调节。（4）脂多糖 (LPS) 和干扰素-γ（IFNG）激活后，PD-L1在T细胞和B细胞、树突状细胞、角质形成细胞和单核细胞中上调，并在表面Ig交联激活的B细胞中上调。PD-L1以白细胞介素-2依赖性方式和程序性细胞死亡1（PDCD1）非依赖性方式参与共刺激信号，该信号对T细胞增殖以及白细胞介素-10（IL10）和IFNG的产生至关重要。
Features and Benefits
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Physical form
兔 IgG，溶于 pH7.4 PBS，0.05％ NaN3，40％ 甘油。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
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The role of B7 family molecules in hematologic malignancy.
Greaves P and Gribben JG
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4301882-100UL | 04061835810574 |