SAB4700480
Monoclonal Anti-CD45-FITC antibody produced in mouse
clone MEM-28, purified immunoglobulin, buffered aqueous solution
别名:
Anti-LCA, Anti-PTPRC
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
FITC conjugate
Clone:
MEM-28, monoclonal
Application:
flow cytometry
Species reactivity:
human
Citations:
7
Technique(s):
flow cytometry: suitable
Uniprot accession no.:
产品名称
Monoclonal Anti-CD45-FITC antibody produced in mouse, clone MEM-28, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MEM-28, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PTPRC(5788)
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Biochem/physiol Actions
Cluster of differentiation 45 (CD45) functions as a prototypic receptor and exhibits phosphatase activity. CD45 is implicated in the regulation of T-cell mediated B cell antigen receptor (BCR)-signaling. The encoded protein plays an essential role in antigen-stimulated proliferation of T lymphocytes and in thymic development. CD45 negatively regulates cytokine receptor signaling via suppressing JAK (Janus kinase) activity.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
The antibody MEM-28 reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets.
The cluster of differentiation 45 (CD45) gene is mapped to human chromosome 1q31.3-q32.1. It codes for a type I transmembrane protein and is expressed in nucleated hematopoietic cells along within its precursors. The protein consists of a varying extracellular domain and a highly conserved intracellular domain.
Immunogen
Human thymocytes and T lymphocytes
Physical form
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.
Taher TE
Clinical Reviews in Allergy & Immunology, 53, 237-264 (2017)
The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state.
Puck A
European Journal of Immunology, 47, 193-205 (2017)
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
Irie-Sasaki J
Nature, 409, 349-354 (2001)
T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity.
Szodoray P
The Journal of Allergy and Clinical Immunology, 138, 839-851 (2016)
I S Trowbridge et al.
Annual review of immunology, 12, 85-116 (1994-01-01)
CD45 is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system. Different isoforms of CD45 are generated by alternative splicing and are expressed in cell type-specific patterns on functional subpopulations
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