SML1087
马来酸舒马尼罗
≥98% (HPLC)
别名:
CID 9818479马来酸酯, PNU-95,666马来酸酯, （5R）-5,6-二氢-5-（甲基氨基）-4H-咪唑并[4,5,1-ij]喹啉-2（1H）-马来酸酯, （R）-5,6-二氢-5-（甲氨基）-4H-咪唑并[4,5,1-ij]喹啉-2（1H）-马来酸酯
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选择尺寸
关于此项目
经验公式（希尔记法）:
C11H13N3O · C4H4O4
化学文摘社编号:
分子量:
319.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
马来酸舒马尼罗, ≥98% (HPLC)
InChI key
VOJRMYBBPKNLLI-ORHWHDKWSA-N
SMILES string
O=C1N(C[C@H](NC)C2)C3=C2C=CC=C3N1.O=C(O)/C=C\C(O)=O
InChI
1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -22 to -32°, c = 1 in H2O
storage condition
desiccated
color
white to beige
solubility
H2O: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
相关类别
Application
苏马尼罗马来酸酯已被用作多巴胺2型受体（D2R）激动剂，用于研究其对大鼠空间学习和记忆的影响。
Biochem/physiol Actions
Sumanirole是一种高度选择性和有效的多巴胺D2受体激动剂。
Sumanirole是一种高度选择性的强效多巴胺D2受体激动剂，可降低黑质致密部中的血浆催乳素水平和降低的多巴胺神经元放电速率。Sumanirole在帕金森病动物模型中可有效刺激运动活动。
Features and Benefits
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Matthew F Lazenka et al.
The Journal of pharmacology and experimental therapeutics, 362(1), 14-23 (2017-04-16)
Clinically significant pain often includes a decrease in both behavior and mesolimbic dopamine signaling. Indirect and/or direct dopamine receptor agonists may alleviate pain-related behavioral depression. To test this hypothesis, the present study compared effects of indirect and direct dopamine agonists
Dopamine type 1-and 2-like signaling in the modulation of spatial reference learning and memory
Feyissa D D, et al.
Behavioural Brain Research, 362, 173-180 (2019)
Spatial working memory in male rats: pre-experience and task dependent roles of dopamine D1-and D2-like receptors
Bezu M, et al.
Frontiers in Behavioral Neuroscience, 11, 196-196 (2017)
L Lencesova et al.
Life sciences, 191, 186-194 (2017-10-22)
Haloperidol is an antipsychotic agent and acts as dopamine D2 receptor (D2R) antagonist, as a prototypical ligand of sigma1 receptors (Sig1R) and it increases expression of type 1 IP We used differentiated NG-108 cells and H9c2 cells. Gene expression, Western
Yasunori Haranishi et al.
Pharmacology, biochemistry, and behavior, 195, 172964-172964 (2020-06-07)
The descending serotonergic pathway, from the brainstem to spinal cord, modulates various aspects of pain processing. The spinal 5-hydroxytryptamine (5-HT)1A and 5-HT2A receptors play pivotal roles in pain modulation. Perospirone is a novel atypical antipsychotic that serves as a 5-hydroxytryptamine
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