T6704

Tandospirone

Name: Tandospirone
Brand: SIGMA

≥98% (HPLC)

别名:

(1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-norbornanedicarboximide citrate salt, SM 3997

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₉N₅O₂

化学文摘社编号:

87760-53-0

分子量:

383.49

UNSPSC Code:

51111800

PubChem Substance ID:

329826853

NACRES:

NA.77

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Quality Level

100

SMILES string

O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1CCCCN4CCN(CC4)c5ncccn5

InChI

1S/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,8-14H2/t15-,16+,17+,18-

InChI key

CEIJFEGBUDEYSX-FZDBZEDMSA-N

assay

≥98% (HPLC)

storage condition

protect from light

solubility

DMSO: 38 mg/mL

originator

Dainippon Sumitomo

storage temp.

2-8°C

Biochem/physiol Actions

Tandospirone is a partial agonist at 5HT_1A receptors.

Tandospirone is a partial agonist at 5HT_1A receptors. It significantly reduces haloperidol-induced bradykinesia in a dose-dependent manner. The potency of tandospirone is equal to that of buspirone and approximate half that of diazepam. The potency of tandospirone as a dopamine antagonistic is less than 1/4 that of buspirone.

Features and Benefits

This compound was developed by Dainippon Sumitomo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.