T6819
抗磷酸化-Tau(pSer199/202) 兔抗
affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-DDPAC, Anti-FTDP-17, Anti-MAPTL, Anti-MSTD, Anti-MTBT1, Anti-MTBT2, Anti-PPND, Anti-PPP1R103, Anti-TAU
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, WB
Citations:
20
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
rat, mouse, human
technique(s)
microarray: suitable, western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer199/pSer202)
Gene Information
human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)
General description
Tau(τ)，别名MAPT（微管相关蛋白tau），由位于人染色体17q21.3上的基因编码。高度表达于神经元细胞，在轴突中浓度最高。
Tau蛋白属微管相关磷蛋白(MAP)，主要在中枢神经系统神经元中表达。在微管蛋白聚合中发挥重要作用，促进微管装配和稳定。tau蛋白的生物活性取决于其磷酸化程度。抗-磷酸化Tau(pSer199/202)抗体可用于微阵列和蛋白质印迹分析(western blotting)。还可用于免疫印迹分析。兔抗-磷酸化Tau (pSer199/202)抗体与人Tau (pSer199/202)(45-68 kD)特异性反应。
Immunogen
化学合成人tau蛋白含丝氨酸199和丝氨酸202区域来源的磷酸肽。
Application
兔生产的抗-磷酸化Tau(pSer199/202)抗体已用于：
- 免疫细胞化学
- 免疫组织化学
- 蛋白质印迹(western blot)
抗-磷酸化Tau (pSer199/202)抗体（用含0.3% Triton X-100和0.5% BSA的PBS1:1000稀释）可用于通过免疫细胞化学法鉴定蛋白聚集体。还可作为一抗（1: 3000稀释）用于免疫组织化学分析。
Biochem/physiol Actions
Tau(τ)在微管结构的组装和维持中起着至关重要的作用。tau(τ)缺失会导致发育迟缓和学习困难。其基因表达与阿尔茨海默症(AD)的发展有关。τ基因变异会提高罹患散发性tau蛋白病(sporadic tauopathies)、进行性核上性麻痹(PSP)和皮质基底节变性的风险。
Physical form
溶于100 μl 杜氏磷酸盐缓冲液（不含Mg2+和Ca2+），pH 7.3，含50%甘油、1.0 mg/ml BSA（IgG，无蛋白酶）和0.05%叠氮化钠。本品的抗体量足够进行10次免疫印迹分析。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
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Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
320.0 °F - closed cup
flash_point_c
160 °C - closed cup
法规信息
常规特殊物品
低风险生物材料
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相关内容
Instructions
Feng-Qin Zhou et al.
Alzheimer's research & therapy, 10(1), 40-40 (2018-04-25)
Alzheimer's disease (AD) is a devastating neurodegenerative disorder bearing multiple pathological hallmarks suggestive of complex cellular/molecular interplay during pathogenesis. Transgenic mice and nonhuman primates are used as disease models for mechanistic and translational research into AD; the extent to which
Tian Tu et al.
Frontiers in aging neuroscience, 12, 93-93 (2020-06-02)
Amyloid plaques and neurofibrillary tangles (NFTs) are hallmark lesions of Alzheimer's disease (AD) related to β-amyloid (Aβ) deposition and intraneuronal phosphorylated tau (pTau) accumulation. Sortilin C-terminal fragments (shortened as "sorfra") can deposit as senile plaque-like lesions within AD brains. The
Yan-Bin Shi et al.
Frontiers in aging neuroscience, 12, 596894-596894 (2020-12-29)
Dystrophic neurites (DNs) are found in many neurological conditions such as traumatic brain injury and age-related neurodegenerative diseases. In Alzheimer's disease (AD) specifically, senile plaques containing silver-stained DNs were already described in the original literature defining this disease. These DNs
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T6819-1VL | 04061838174512 |