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Merck
CN

T7830

TFLLR-NH2 trifluoroacetate salt

>98% (HPLC)

别名:

L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt, Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt

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关于此项目

经验公式（希尔记法）:
C31H53N9O6 · xC2HF3O2
化学文摘社编号:
1313730-19-6
分子量:
647.81 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
329826874
UNSPSC Code:
12352200
MDL number:
MFCD05663482
Assay:
>98% (HPLC)
Form:
lyophilized powder
Quality level:
100

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产品名称

TFLLR-NH2 trifluoroacetate salt, >98% (HPLC)

InChI

1S/C31H53N9O6.C2HF3O2/c1-17(2)14-22(27(43)37-21(26(33)42)12-9-13-36-31(34)35)38-28(44)23(15-18(3)4)39-29(45)24(16-20-10-7-6-8-11-20)40-30(46)25(32)19(5)41;3-2(4,5)1(6)7/h6-8,10-11,17-19,21-25,41H,9,12-16,32H2,1-5H3,(H2,33,42)(H,37,43)(H,38,44)(H,39,45)(H,40,46)(H4,34,35,36);(H,6,7)/t19-,21+,22+,23+,24+,25+;/m1./s1

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

InChI key

QVNWOGSDGQDGHP-MKVNCOEFSA-N

assay

>98% (HPLC)

form

lyophilized powder

color

white to tan

solubility

H2O: >2 mg/mL

storage temp.

−20°C

Quality Level

100

相关类别

Application

TFLLR-NH2 trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).

Biochem/physiol Actions

TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2.
TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.

Preparation Note

TFLLR-NH2 trifluoroacetate is soluble in water at a concentration that is greater than 2 mg/ml.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000451031
0000451031
0000360802
0000360802
0000139534

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Glutamate-releasing SWELL1 channel in astrocytes modulates synaptic transmission and promotes brain damage in stroke
Yang J, et al.
Neuron, 102(4), 813-827 (2019)
Hui Sun et al.
American journal of physiology. Lung cellular and molecular physiology, 318(1), L192-L199 (2019-10-31)
We evaluated the mechanisms underlying protease-activated receptor 1 (PAR1)-mediated activation of nodose C-fibers in mouse lungs. The PAR1-induced action potential discharge at the terminals was strongly inhibited in phospholipase C-β3 (PLCβ3)-deficient animals. At the level of the cell soma, PAR1
Junhua Yang et al.
Neuron, 102(4), 813-827 (2019-04-16)
By releasing glutamate, astrocytes actively regulate synaptic transmission and contribute to excitotoxicity in neurological diseases. However, the mechanisms of astrocytic glutamate release have been debated. Here, we report non-vesicular release of glutamate through the glutamate-permeable volume-regulated anion channel (VRAC). Both

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