所有图片(1)

文件

1607007

USP

糖精

Name: 糖精
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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别名:

2,3-二羟基-1,2-苯并异噻唑基-3-酮-1,1-二氧化物, 2-磺基苯甲酸亚胺, 邻磺酰苯酰亚胺

经验公式（希尔记法）:

C₇H₅NO₃S

CAS号:

81-07-2

分子量:

183.18

Beilstein:

6888

MDL编号:

MFCD00005866

PubChem化学物质编号:

329751066

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

saccharin

manufacturer/tradename

USP

mp

226-229 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

SMILES string

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

InChI key

CVHZOJJKTDOEJC-UHFFFAOYSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Saccharin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

生化/生理作用

哺乳动物的甜促味剂。有人提出，果蝇具有葡萄糖特异性甘油味觉受体结合位点。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Selective breeding for differential saccharin intake as an animal model of drug abuse.

Marilyn E Carroll et al.

Behavioural pharmacology, 19(5-6), 435-460 (2008-08-12)

A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence

The health risks of saccharin revisited.

L B Ellwein et al.

Critical reviews in toxicology, 20(5), 311-326 (1990-01-01)

Almost from its discovery in 1879, the use of saccharin as an artificial, non-nutritive sweetener has been the center of several controversies regarding potential toxic effects, most recently focusing on the urinary bladder carcinogenicity of sodium saccharin in rats when

An hypothesis of the mechanism of urinary bladder tumorigenesis in rat ingesting sodium saccharin.

R L Anderson

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(7), 637-644 (1988-07-01)

An hypothesis is presented of a mechanism for the sodium saccharin (NaS)-associated tumorigenesis of the urinary bladder that occurs in male rats. The ingestion of high doses of NaS is associated with increased urine volume and bladder mass. In rats

The disposition of saccharin in animals and man--a review.

A G Renwick

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 23(4-5), 429-435 (1985-04-01)

Recent studies on saccharin in animals and man have allowed a detailed understanding of its fate in the body. Saccharin is slowly absorbed from the gut but rapidly eliminated in the urine, largely by renal tubular secretion. Saccharin does not

Saccharin: a toxicological and historical perspective.

D L Arnold et al.

Toxicology, 27(3-4), 179-256 (1983-07-01)

Saccharin, first synthesized in 1879, eventually became popular as an inexpensive substitute for sugar, particularly as a non-caloric sweetner. The dispute concerning the safety of saccharin for human consumption is almost as old as saccharin itself. In this article, the

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糖精