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Assignment1 of the gene of mitochondrial branched chain aminotransferase (BCAT2) to sheep chromosome band 14q24 and to cattle and goat chromosome bands 18q24 by in situ hybridization.
M Faure et al.
Cytogenetics and cell genetics, 83(1-2), 96-97 (1999-02-02)
Zhao Yanbin et al.
Biochemical and biophysical research communications, 516(1), 102-111 (2019-06-16)
Here, we firstly examined the proliferation and invasion capacities of different osteosarcoma (OS) cell lines, and analyzed the profiling of the differentially expressed circular RNAs(circRNAs). Then, we identified a novel circRNA(circ_101356/circ_0004846, we named circSAMD4 in the present study) and found
Ana Hagiu et al.
Clinical oral investigations, 24(7), 2375-2383 (2019-10-28)
This in vitro study aimed to analyze the anti-inflammatory and wound healing potential of green tea extract (GTE) in human gingival epithelial keratinocytes (HGEK) treated with lipopolysaccharides (LPS). A cell viability assay was conducted using MTT to determine nontoxic levels
Dries A M Feyen et al.
Cell reports, 32(3), 107925-107925 (2020-07-23)
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential for the study of human cardiac disorders. However, their physiological immaturity severely limits their utility as a model system and their adoption for drug discovery. Here, we describe maturation media designed
Ting Cai et al.
Cell death & disease, 11(5), 390-390 (2020-05-24)
Inhibition of sodium-glucose cotransporter 2 (SGLT2) in the proximal tubule of the kidney has emerged as an effective antihyperglycemic treatment. The potential protective role of SGLT2 inhibition on diabetic kidney disease (DKD) and underlying mechanism, however, remains unknown. In this
T Miyazawa et al.
International journal of peptide and protein research, 40(1), 49-53 (1992-07-01)
In segment couplings by the mixed anhydride method using isobutyloxycarbonyl chloride, the use of copper(II) chloride as an additive suppressed racemization completely in the same manner as in the carbodiimide method reported previously. This was confirmed by employing a number
S. Danishefsky et al
Tetrahedron Letters, 25, 4203-4203 (1984)
Sarah S Wilson et al.
Frontiers in immunology, 11, 547102-547102 (2021-03-02)
Diligent side-by-side comparisons of how different methodologies affect growth efficiency and quality of intestinal colonoids have not been performed leaving a gap in our current knowledge. Here, we summarize our efforts to optimize culture conditions for improved growth and functional
Aejin Lee et al.
Journal of dairy science, 102(10), 8614-8621 (2019-07-29)
Bovine colostrum (BC) has been used for nutraceutical purposes for animals and humans. Bovine colostrum is a complex heterogeneous product and its antimicrobial activity, antioxidant potential, and growth factors can vary depending on age and species of the cow as
Kathleen M McAvoy et al.
PloS one, 14(8), e0220125-e0220125 (2019-08-14)
BIN1 is the most important risk locus for Late Onset Alzheimer's Disease (LOAD), after ApoE. BIN1 AD-associated SNPs correlate with Tau deposition as well as with brain atrophy. Furthermore, the level of neuronal-specific BIN1 isoform 1 protein is decreased in
J. Cabre et al.
Synthesis, 413-413 (1984)
Qing Li et al.
Arthritis & rheumatology (Hoboken, N.J.), 72(8), 1266-1277 (2020-03-13)
To elucidate the role of decorin, a small leucine-rich proteoglycan, in the degradation of cartilage matrix during the progression of post-traumatic osteoarthritis (OA). Three-month-old decorin-null (Dcn-/- ) and inducible decorin-knockout (DcniKO ) mice were subjected to surgical destabilization of the
Liza L Ramenzoni et al.
Materials (Basel, Switzerland), 12(9) (2019-05-01)
Improving soft tissue attachment to implant abutments is a crucial factor for enduring health and maintenance of soft peri-implant tissue health. In this in vitro study we aimed to compare the biocompatibility of three different abutment surfaces: titanium, zirconia and
Simon Pecha et al.
Scientific reports, 9(1), 9831-9831 (2019-07-10)
Human iPSC-derived engineered heart tissue (hEHT) has been used to remuscularize injured hearts in a guinea pig infarction model. While beneficial effects on cardiac remodeling have been demonstrated, the arrhythmogenic potential of hEHTs is a major concern. We investigated whether
Nonionic surfactants regioselective synthesis of fatty acid esters of alpha- and beta-glucopyranose.
D De Luca et al.
Lipids, 32(5), 559-563 (1997-05-01)
Lipophilic esters of saccharides belong to the family of nonionic surfactants widely employed in pharmaceutical and cosmetics formulations. A very simple method is presented whereby 6-O-esters of alpha- and beta-glucose can be prepared and isolated. Good results have been obtained
Trace Thome et al.
American journal of physiology. Cell physiology, 317(4), C701-C713 (2019-07-11)
Chronic kidney disease (CKD) leads to increased skeletal muscle fatigue, weakness, and atrophy. Previous work has implicated mitochondria within the skeletal muscle as a mediator of muscle dysfunction in CKD; however, the mechanisms underlying mitochondrial dysfunction in CKD are not
H T Le et al.
Bioorganic & medicinal chemistry, 4(12), 2201-2209 (1996-12-01)
BOP-Cl was found to be an efficient coupling reagent for the introduction of thiopeptide bonds on imino acid residues (Pro, Sar). Boc-amino monothioacids were coupled at moderate temperature (0 degree C-RT) with fair yields and with retained optical purity. The
Jothi Varghese et al.
Materials (Basel, Switzerland), 12(23) (2019-11-30)
This study aimed to assess the biofilm reduction, staining potential, and cytotoxicity of guava extract mouth rinse compared to chlorhexidine (CHX). Substantivity, staining, and antibiofilm potential were investigated by spectrophotometry, colony-forming units, and luminosity color meter, respectively. The cell viability
Zina Fredj et al.
Analytical methods : advancing methods and applications, 12(31), 3883-3891 (2020-07-28)
A silver nanoparticle and copper monoamino-phthalocyanine-acrylate (Cu-MAPA) polymer modified glassy carbon electrode was developed for the simultaneous detection of dopamine (DOP), ascorbic acid (AA) and uric acid (UA) using voltammetric techniques. Silver nanoparticles (AgNPs) were synthesised according to the citrate
Yanjie Xu et al.
Molecules (Basel, Switzerland), 10(1), 259-264 (2007-11-17)
Hexadepsipeptide 2, the precursor of Hirsutellide A (1), was synthesized in an overall yield of 45% from N-Boc-Me-Gly via three coupling reactions using dicyclohexylcarbodiimide (DCC), O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyl- uronium hexafluorophosphate (HATU) and bis(2-oxo-3-oxazolidinyl)phosphinic chloride (BOP-Cl), respectively.
Umber Saleem et al.
Toxicological sciences : an official journal of the Society of Toxicology, 176(1), 103-123 (2020-05-19)
Animal models are 78% accurate in determining whether drugs will alter contractility of the human heart. To evaluate the suitability of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for predictive safety pharmacology, we quantified changes in contractility, voltage, and/or Ca2+ handling
R.D. Tung et al.
Journal of the American Chemical Society, 107, 4342-4342 (1985)
Maddalena Nano et al.
Current biology : CB, 29(22), 3937-3945 (2019-11-12)
Polyploidy arises from the gain of complete chromosome sets [1], and it is known to promote cancer genome evolution. Recent evidence suggests that a large proportion of human tumors experience whole-genome duplications (WGDs), which might favor the generation of highly
E.J. Corey et al.
Journal of the American Chemical Society, 104, 6818-6818 (1982)
I de Aós et al.
The Journal of biological chemistry, 272(40), 25310-25318 (1997-10-06)
T cell receptor signaling results both in T cell proliferation and apoptosis. A key enzyme at the intersection of these downstream pathways is phosphatidylinositol 3'-kinase (PI 3-kinase). In a previous report, we showed that the p85alpha subunit of the PI
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