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Andrei Ponta et al.
Journal of drug targeting, 22(7), 619-628 (2014-04-29)
Nanoparticles are widely used as drug carriers for controlled, tumor-targeted delivery of various anticancer agents that have biopharmaceutical limitations such as water solubility and tissue permeability. Growing evidence suggests that nanoparticles not only reduce toxic side effects of anticancer drugs
Matthew T Holden et al.
Analytical chemistry, 87(22), 11420-11428 (2015-10-24)
The photolithographic fabrication of high-density DNA and RNA arrays on flexible and transparent plastic substrates is reported. The substrates are thin sheets of poly(ethylene terephthalate) (PET) coated with cross-linked polymer multilayers that present hydroxyl groups suitable for conventional phosphoramidite-based nucleic
Tong Zhang et al.
Journal of chromatography. A, 1363, 191-199 (2014-06-26)
CHIRALPAK ZWIX(+) and ZWIX(-) are cinchona alkaloid-derived zwitterionic chiral stationary phases (CSPs) containing a chiral sulfonic acid motif which serves as negatively charged interaction site. They are versatile for direct enantiomer resolution of amino acids and many other ampholytic compounds
Anne-Laure Papa et al.
Dalton transactions (Cambridge, England : 2003), 44(2), 739-746 (2014-11-20)
In the present study, we report the dispersion of titanate nanotubes (TiONts) via polymer grafting (PolyEthylene Glycol, PEG) or polymer adsorption (polyethylene imine, PEI) where different TiONts/polymer ratios have been investigated. The TiONts/PEI and TiONts/PEG nanohybrids were characterized by scanning
Qinhua Huang et al.
Journal of medicinal chemistry, 58(6), 2821-2833 (2015-03-03)
The antiglaucoma drugs dorzolamide (1) and brinzolamide (2) lower intraocular pressure (IOP) by inhibiting the carbonic anhydrase (CA) enzyme to reduce aqueous humor production. The introduction of a nitric oxide (NO) donor into the alkyl side chain of dorzolamide (1)
Shashi Gandhi et al.
Experimental parasitology, 149, 16-23 (2014-12-17)
Serine hydroxymethyltransferase belongs to the class of pyridoxal-5-phosphate enzymes along with aspartate aminotransferase. To explore the function of residue(s) involved in binding of the carboxylate group of Tetrahydrofolic acid (THF) to L. donovani cytosolic serine hydroxymethyltransferase (LdcSHMT), the gene was
Johnson Agniswamy et al.
Journal of medicinal chemistry, 56(10), 4017-4027 (2013-04-18)
Extreme drug resistant mutant of HIV-1 protease (PR) bearing 20 mutations (PR20) has been studied with the clinical inhibitor amprenavir (1) and two potent antiviral investigational inhibitors GRL-02031 (2) and GRL-0519 (3). Clinical inhibitors are >1000-fold less active on PR20
Snahel Patel et al.
Journal of medicinal chemistry, 58(1), 401-418 (2014-10-24)
Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation of potent and selective DLK inhibitors starting from a high-throughput screening hit. Using proposed hinge-binding interactions
Alison E Mahan et al.
Journal of immunological methods, 417, 34-44 (2014-12-20)
The N-glycan of the IgG constant region (Fc) plays a central role in tuning and directing multiple antibody functions in vivo, including antibody-dependent cellular cytotoxicity, complement deposition, and the regulation of inflammation, among others. However, traditional methods of N-glycan analysis
Chenchen Guo et al.
Pharmaceutical research, 31(11), 3051-3059 (2014-05-09)
The acne skin is characteristic of a relatively lower pH microenvironment compared to the healthy skin. The aim of this work was to utilize such pH discrepancy as a site-specific trigger for on-demand topical adapalene delivery. The anti-acne agent, adapalene
Daniel M Shadrack et al.
International journal of molecular sciences, 16(11), 26363-26377 (2015-11-12)
The biomedical potential of flavonoids is normally restricted by their low water solubility. However, little has been reported on their encapsulation into polyamidoamine (PAMAM) dendrimers to improve their biomedical applications. Generation four (G4) PAMAM dendrimer containing ethylenediaminetetraacetic acid core with
Hyo Jin Kang et al.
Biosensors & bioelectronics, 67, 413-418 (2014-09-15)
Caspase-3 is an apoptotic cysteine protease and its aberrancy is highly implicated to numerous diseases thereby rendering caspase-3 activity as an important disease marker. Most caspase-3 sensors are caspase-3 substrates of which the fluorescence signals are turned on upon catalytic
C Preston Pugh et al.
Archives of biochemistry and biophysics, 564, 244-253 (2014-12-03)
The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may modulate warfarin metabolism transcriptionally or through direct inhibition of cytochromes P450 and thus, UGT action toward hydroxywarfarin
Gyan P Mishra et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 397-405 (2014-06-17)
Biodegradable poly(ethyleneglycol)-poly(valerolactone)-poly(ethyleneglycol) [PEG-PVL-PEG] copolymers were synthesized through ring opening polymerization of δ-valerolactone (VL) followed by the coupling of monomethoxy poly(ethyleneglycol-poly(valerolactone) (mPEG-PVL) with hexamethylene diisocyanate (HDI). The copolymers were characterized by (1)H NMR, FT-IR, and GPC. Block copolymers of PEG and
Lobna Abdel Aziz Hussein et al.
Journal of AOAC International, 97(4), 1175-1182 (2014-08-26)
This work deals with spectrophotometric, spectrofluorimetric, and potentiometric analyses of cetyltrimethylammonium bromide (CTAB) cationic detergent. The spectrophotometric procedure depends on measuring the absorbance of its binary complex with eosin yellow in Britton-Robinson buffer (pH 4) at Lambda max 547 nm
Menglin Wang et al.
Biomacromolecules, 16(4), 1179-1190 (2015-02-26)
To improve the bioavailability of orally administered drugs, we synthesized a pH-sensitive polymer (poly(ethylene glycol)-poly(2-methyl-2-carboxyl-propylene carbonate)-vitamin E, mPEG-PCC-VE) attempting to integrate the advantages of enteric coating and P-glycoprotein (P-gp) inhibition. The aliphatic polycarbonate chain was functionalized with carboxyl groups and
L Horev et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 29(4), 761-766 (2014-09-02)
Preservatives are important and frequent skin sensitizers, found in a wide range of products for personal and occupational use. According to the European legislation, some cosmetic ingredients are restricted in terms of quantity and a detailed list of ingredients must
Renato Cardoso Tudela et al.
Protein and peptide letters, 22(12), 1111-1116 (2015-10-09)
Kinins are important vasoactive peptides, but the role of the B1 receptor subtype in the vascular control is poorly understood. This study analyzed the nitric oxide (NO) release, L-arginine (L-Arg) uptake and the expression of the cationic amino acid transporter
Diffusive hydrogen inter-cage migration in hydrogen and hydrogen-tetrahydrofuran clathrate hydrates.
Huayu Cao et al.
The Journal of chemical physics, 138(9), 094507-094507 (2013-03-15)
Classical equilibrium molecular dynamics simulations have been performed to investigate the diffusive properties of inter-cage hydrogen migration in both pure hydrogen and mixed hydrogen-tetrahydrofuran sII hydrates at 0.05 kbar from 200 K and up to 250-260 K. For mixed H2-THF
Zhao Zhang et al.
Dalton transactions (Cambridge, England : 2003), 44(13), 6229-6241 (2015-03-05)
In the series of homo-leptic trinuclear complexes {[Ln3(L)4Cl4(MeOH)(H2O)]·Cl} (Ln = La, 1; Ln = Eu, 2; Ln = Tb, 3 or Ln = Gd, 4) self-assembled from the allyl-modified benzimidazole-type ligand HL (4-allyl-2-(1H-benzo[d]imidazol-2-yl)-6-methoxyphenol) and LnCl3·6H2O, a suitable energy level match
Wangyang Li et al.
ACS applied materials & interfaces, 7(47), 26094-26100 (2015-11-11)
An aggregation-enhanced emission active luminogen named as sodium 4,4'4″-(3,4-diphenyl-1H-pyrrole-1,2,5-triyl)tribenzoate (DP-TPPNa) with propeller construction was synthesized and developed as a "turn on" fluorescent probe for in situ quantitation of albumin in blood serum. The DP-TPPNa fluorescence intensity was linearly correlated with
Maxence Urbani et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(45), 16252-16265 (2015-09-12)
The detailed synthesis and characterization of four ruthenium(II) complexes [RuLL'(NCS)2 ] is reported, in which L represents a 2,2'-bipyridine ligand functionalized at the 4,4' positions with benzo[1,2-b:4,5-b']dithiophene derivatives (BDT) and L' is 2,2'-bipyridine-4,4'-dicarboxylic acid unit (dcbpy) (NCS=isothiocyanate). The reaction conditions
Fabrice Giusti et al.
The Journal of membrane biology, 247(9-10), 909-924 (2014-03-22)
Amphipols are short amphipathic polymers that can substitute for detergents at the hydrophobic surface of membrane proteins (MPs), keeping them soluble in the absence of detergents while stabilizing them. The most widely used amphipol, known as A8-35, is comprised of
Rangaswamy Suganya et al.
DNA repair, 27, 40-48 (2015-02-04)
The mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is an essential DNA repair/gene regulatory protein. Decrease of APE1 in cells by inducible shRNA knockdown or by conditional gene knockout caused apoptosis. Here we succeeded in establishing a unique mouse embryonic fibroblast
Neil R Marshall et al.
Experimental neurology, 263, 79-90 (2014-09-24)
Injection of lysosomal enzyme into cisternal or ventricular cerebrospinal fluid (CSF) has been carried out in 11 lysosomal storage disorder models, with each study demonstrating reductions in primary substrate and secondary neuropathological changes, and several reports of improved neurological function.
Abhinay Mishra et al.
Journal of biomedical materials research. Part A, 103(12), 3798-3806 (2015-06-23)
Long-term in vitro stability of thermoplastic polyurethanes (TPUs) was studied for up to 52 weeks in phosphate buffer solution at 37, 55, and 80°C. Water uptake, molecular weights, and tensile properties were measured at regular intervals of 4, 8, 16
Marta Soler et al.
Inorganic chemistry, 54(22), 10542-10558 (2015-10-28)
The conjugation of redox-active complexes that can function as chemical nucleases to cationic tetrapeptides is pursued in this work in order to explore the expected synergistic effect between these two elements in DNA oxidative cleavage. Coordination complexes of biologically relevant
Hui Yin et al.
International journal of pharmaceutics, 483(1-2), 169-179 (2015-02-15)
A new CD44-targeted gene delivery system, the star-shaped cationic polymer containing a β-cyclodextrin (β-CD) core and multiple branched oligoethylenimine (OEI) arms with conjugated oligomer of hyaluronic acid (HA), was synthesized by reductive amination between β-CD-OEI star polymer and HA, and
Antoine Frère et al.
Biomacromolecules, 16(3), 769-779 (2015-01-21)
RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium- and morpholino-functionalized biocompatible and biodegradable polycarbonate vectors. The
Sanjib Banerjee et al.
Journal of chromatography. A, 1376, 98-104 (2014-12-24)
The chemical homogeneity of telechelic polyisobutylene diol (PIB-diol), prepared by hydroboration-oxidation of allyl telechelic PIB obtained by reacting living PIB with allyltrimethylsilane, was investigated by liquid chromatography at critical conditions (LCCC) and HPLC coupled with matrix-assisted laser desorption/ionization time-of-flight mass
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