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显示 31-60 共 325 条结果 关于 "178810" 范围 论文
Timothy Plett et al.
Nanoscale, 7(45), 19080-19091 (2015-11-03)
Nanopores have become a model system to understand transport properties at the nanoscale. We report experiments and modeling of ionic current in aprotic solvents with different dipole moments through conically shaped nanopores in a polycarbonate film and through glass nanopipettes.
Shigeo Hayashi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage
Kazunori Shimomura et al.
Tissue engineering. Part A, 21(13-14), 2066-2075 (2015-03-31)
Radial tears of the meniscus represent one of the most common injuries of the knee, and result in loss of biomechanical meniscal function. However, there have been no established, effective treatments for radial meniscal tears. Nanofibrous materials produced by electrospinning
Satoru Matsukawa et al.
Molecules (Basel, Switzerland), 20(10), 18482-18495 (2015-10-17)
The ring-opening of N-tosylaziridines with various acid anhydrides catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) afforded the corresponding β-amino esters in excellent yields under mild reaction conditions. Polymer-supported catalyst, PS-TBD also acts as a good catalyst for this reaction.
Ibtissam Talhaoui et al.
Nucleic acids research, 42(10), 6300-6313 (2014-04-03)
The human thymine-DNA glycosylase (TDG) initiates the base excision repair (BER) pathway to remove spontaneous and induced DNA base damage. It was first biochemically characterized for its ability to remove T mispaired with G in CpG context. TDG is involved
Vittorio Pace et al.
ChemSusChem, 5(8), 1369-1379 (2012-08-14)
2-Methyl-tetrahydrofuran (2-MeTHF) can be derived from renewable resources (e.g., furfural or levulinic acid) and is a promising alternative solvent in the search for environmentally benign synthesis strategies. Its physical and chemical properties, such as its low miscibility with water, boiling
Luca Chiari et al.
The Journal of chemical physics, 138(7), 074301-074301 (2013-03-01)
We present total, elastic, and inelastic cross sections for positron and electron scattering from tetrahydrofuran (THF) in the energy range between 1 and 5000 eV. Total cross sections (TCS), positronium formation cross sections, the summed inelastic integral cross sections (ICS)
Lavanya Y Peddada et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 103-112 (2014-09-07)
The clinical application of gene silencing is hindered by poor stability and low delivery efficiency of naked oligonucleotides. Here, we present the in vitro and in vivo behaviors of a rationally designed, ternary, self-assembled nanoparticle complex, consisting of an anionic
Esteban F Durán-Lara et al.
Biomacromolecules, 16(11), 3434-3444 (2015-10-16)
Lysine-containing polymers have seen broad application due to their amines' inherent ability to bind to a range of biologically relevant molecules. The synthesis of multiple generations of polyester dendrimers bearing lysine groups on their periphery is described in this report.
Abhijit Achyut Gurjarpadhye et al.
Tissue engineering. Part C, Methods, 21(7), 758-766 (2014-12-30)
Lumen endothelialization of bioengineered vascular scaffolds is essential to maintain small-diameter graft patency and prevent thrombosis postimplantation. Unfortunately, nondestructive imaging methods to visualize this dynamic process are lacking, thus slowing development and clinical translation of these potential tissue-engineering approaches. To
Stephen W C Chung et al.
Journal of agricultural and food chemistry, 62(25), 5805-5811 (2014-06-06)
This paper reports the development of a method for the quantitative analysis of perfluorinated compounds (PFCs), including C6-C14 perfluorinated carboxylic acids (PFCAs) and C4-C12 perfluorinated sulfonates (PFSAs), in fish and fatty foods by ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS)
Vito Fasano et al.
Macromolecules, 48(21), 7803-7809 (2015-12-01)
Electrospinning in controlled nitrogen atmosphere is developed for the realization of active polymer nanofibers. Fibers electrospun under controlled atmospheric conditions are found to be smoother and more uniform than samples realized by conventional electrospinning processes performed in air. In addition
Alfredo Ronca et al.
Journal of biomaterials applications, 29(5), 715-727 (2014-06-22)
The discovery of new strategies to repair large segmental bone defects is currently an open challenge for worldwide clinicians. In the treatment of critical-sized bone defects, an alternative strategy to traditional bone grafting is always more frequently the use of
Ibrahim H A Badr et al.
Carbohydrate polymers, 134, 687-694 (2015-10-03)
Bacterial cellulose (BC) and heparin-modified bacterial cellulose (HBC) were utilized to enhance the biocompatibility of highly thrombogenic PVC-based potassium and calcium membrane electrodes. Three types of membrane electrodes were prepared: (1) conventional PVC electrode (control), (2) PVC-based electrode sandwiched with
Yunqi Li et al.
Chemistry, an Asian journal, 10(1), 183-187 (2014-09-12)
A triblock copolymer, poly(styrene-b-2-vinyl pyridine-b-ethylene oxide) (PS-b-P2VP-b-PEO) was used as a soft template to synthesize large-sized mesoporous phosphosilicate thin films. The kinetically frozen PS core stabilizes the micelles. The strong interaction of the inorganic precursors with the P2VP shell enables
Xiu-Ying Chen et al.
International journal of nanomedicine, 10, 2765-2774 (2015-04-22)
The use of triptolide (TP) is limited by its poor water solubility and severe toxicity. In this study, we developed an active drug delivery system (TP-loaded nanoparticles) that could help improve the water solubility of TP and decrease its toxicity.
Shing Fung Chow et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 462-471 (2014-07-16)
The relative performance of two specially designed mixers for nanoparticle production, namely, two-stream confined impinging jets with dilution mixer (CIJ-D-M) and four-stream multi-inlet vortex mixer (MIVM), was evaluated using the model compound, curcumin (CUR), under defined conditions of varying mixing
Ravi Bhushan et al.
Journal of chromatography. A, 1379, 43-50 (2015-01-13)
Five d-amino acids have been used for the first time to synthesize chiral derivatizing reagents (as variants of Marfey's reagent) by nucleophilic displacement of one of the fluorine atoms in 1,5-difluoro-2,4-dinitrobenzene as against the literature reports on application of only
Yonggang Wang et al.
Environmental science & technology, 46(21), 11761-11769 (2012-09-15)
Experimental and mathematical modeling studies were performed to examine the effects of stabilizing agents on the transport and retention of fullerene nanoparticles (nC(60)) in water-saturated quartz sand. Three stabilizing systems were considered: naturally occurring compounds known to stabilize nanoparticles (Suwannee
Damien Hanlon et al.
Nature communications, 6, 8563-8563 (2015-10-16)
Few-layer black phosphorus (BP) is a new two-dimensional material which is of great interest for applications, mainly in electronics. However, its lack of environmental stability severely limits its synthesis and processing. Here we demonstrate that high-quality, few-layer BP nanosheets, with
Zhenchang Liang et al.
PloS one, 9(8), e105146-e105146 (2014-08-19)
Grapes are rich in phytochemicals with many proven health benefits. Phenolic profiles, antioxidant and antiproliferative activities of twenty-four selected Vitis vinifera grape cultivars were investigated in this study. Large ranges of variation were found in these cultivars for the contents
Hsiao-yin Yang et al.
Pharmaceutical research, 32(2), 680-690 (2014-08-29)
To develop a bio-assay for measuring long-term bioactivity of released anti-inflammatory compounds and to test the bioactivity of celecoxib (CXB) and triamcinolone acetonide (TA) released from a new PLGA-based microsphere platform. Human osteoarthritic chondrocytes were plated according to standardized procedures
Bernhard Sandig et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(44), 15835-15842 (2015-10-24)
Mesoporous monolithic hybrid cellulose-2.5-acetate (CA)/polymer supports were prepared under solvent-induced phase separation conditions using cellulose-2.5-acetate microbeads 8-14 μm in diameter, 1,1,1-tris(hydroxymethyl)propane and 4,4'-methylenebis(phenylisocyanate) as monomers as well as THF and n-heptane as porogenic solvents. 4-(Dimethylamino)pyridine and dibutyltin dilaurate (DBTDL), respectively, were
Emilie Destandau et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 29-37 (2015-02-04)
An innovative procedure coupling pressurized solvent extraction and centrifugal partition chromatography (CPC) used in linear gradient elution mode was developed to isolate two pure germacranolides (9α-hydroxyparthenolide and 9β-hydroxyparthenolide) and to separate flavonoids (nepetin, isorhamnetin and jaceosidin) and chlorophyll pigments from
Tsubasa Oyama et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(11), 1129-1135 (2015-11-13)
A fully-automated on-line oxidation column-switching HPLC system has been developed for the determination of endogenous melatonin in human plasma and saliva. This HPLC system consists of four processes. In the first step, melatonin is fractionated using a reversed-phase C4 column
Shaily Mahendra et al.
Environmental science & technology, 40(17), 5435-5442 (2006-09-27)
1,4-Dioxane is a probable human carcinogen, and an important emerging water contaminant. In this study, the biodegradation of dioxane by 20 bacterial isolates was evaluated, and 13 were found to be capable of transforming dioxane. Dioxane served as a growth
Xuejia Zhai et al.
Journal of pharmaceutical and biomedical analysis, 107, 450-455 (2015-02-11)
Chronic stress as well as major depressive disorders is associated with cortisol metabolism. Two enzymes modulate cortisol (F) and cortisone (E) interconversion: 11β-hydroxysteroid dehydrogenase type 1 and type 2 (11β-HSD1 and 11β-HSD2). Furthermore, F and E were inactivated by 5α
Mamdouh R Rezk et al.
Journal of chromatographic science, 52(7), 704-706 (2013-07-13)
This work describes a simple and sensitive method for simultaneous determination of zolmitriptan, naproxen and propranolol in their dosage forms using HPLC. The drugs were separated isocratically on a Zorbax C8 (4.6 × 250 mm with 5 µm particle size)
Tetrahydrofuran poisoning after occupational exposure.
R Garnier et al.
British journal of industrial medicine, 46(9), 677-678 (1989-09-01)
Judith A Egan et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 94, 302-305 (2014-10-12)
Methods are presented to tritiate the enzyme inhibitors pargyline and caracemide.
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