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关键词:'186562'
显示 1-30 共 521 条结果 关于 "186562" 范围 论文
Ping Huang et al.
Pharmaceutical research, 32(7), 2328-2343 (2015-01-17)
A novel hydrophilic conjugate of arginine-glycine-aspartic acid (RGD) and polyethylene glycol (PEG), i.e., RGD-PEG Mw (M W = 300, 600, 1000 or 4000), was synthesized and employed in epirubicin (EPI) loaded poly L-lactic acid (PLLA) nanoparticles (NPs) to improve its
V Mistretta et al.
Acta clinica Belgica, 69(1), 53-61 (2014-03-19)
Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major active metabolite, hydroxy-itraconazole) in serum can be useful
Hwee Ling Poh et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(22), 8130-8136 (2015-04-17)
Covalently functionalized graphene materials with well-defined stoichiometric composition are of a very high importance in the research of 2D carbon material family due to their well-defined properties. Unfortunately, most of the contemporary graphene-functionalized materials do not have this kind of
Divyabharathi Chepyala et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 48-54 (2015-01-16)
Recently, colistin has become one of the most important drugs for treating infections caused by multidrug-resistant Gram-negative bacteria. Therapeutic drug monitoring is recommended to ensure the safety and efficacy of colistin and to improve clinical outcomes. This study developed an
Hang Wang et al.
Analytica chimica acta, 882, 49-57 (2015-06-05)
Hydrophobic compounds with hydroxyl, aldehyde or ketone groups are generally difficult to detect using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), because these compounds have low proton affinity and are poorly ionized by MALDI. Herein, coumarins have been used as new
Kaiwen Chang et al.
Small (Weinheim an der Bergstrasse, Germany), 10(21), 4270-4275 (2014-07-23)
Stable full-color fluorescence patterning are achieved by multicolor polymer-dot inks. The fluorescent patterns show extraordinary stability upon various treatments, offering a superior combination of bright fluorescence, excellent photostability, chemical resistance, and eco-friendship.
Valentino Ruggieri et al.
BMC plant biology, 14, 337-337 (2014-12-04)
Genome Wide Association Studies (GWAS) have been recently used to dissect complex quantitative traits and identify candidate genes affecting phenotype variation of polygenic traits. In order to map loci controlling variation in tomato marketable and nutritional fruit traits, we used
Temmei Ito et al.
Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)
In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)
C N Ong et al.
British journal of industrial medicine, 48(9), 616-621 (1991-09-01)
Occupational exposure to tetrahydrofuran (THF) was studied by analysis of environmental air, blood, alveolar air, and urine from 58 workers in a video tape manufacturing plant. Head space gas chromatography (GC) with an FID detector was used for determination of
Roccaldo Sardella et al.
Journal of separation science, 37(19), 2696-2703 (2014-07-22)
With the present contribution, we demonstrate that the baseline separation of ketoprofen enantiomers can be successfully achieved (α = 1.09; R(S) = 1.60) in the reversed-phase mode of elution with a commercially available anion-exchange-based chiral stationary phase, incorporating the quinine
Alicia J Sawdon et al.
Colloids and surfaces. B, Biointerfaces, 122, 738-745 (2014-09-07)
Polymeric prodrug micelles for delivery of acyclovir (ACV) were synthesized. First, ACV was used directly to initiate ring-opening polymerization of ɛ-caprolactone to form ACV-polycaprolactone (ACV-PCL). Through conjugation of hydrophobic ACV-PCL with hydrophilic methoxy poly(ethylene glycol) (MPEG) or chitosan, polymeric micelles
Heather Ordonez et al.
Nucleic acids research, 42(20), 12722-12734 (2014-10-30)
Mycobacterium smegmatis DinB2 is the founder of a clade of Y-family DNA polymerase that is naturally adept at utilizing rNTPs or dNTPs as substrates. Here we investigate the fidelity and lesion bypass capacity of DinB2. We report that DinB2 is
Isabelle Laverdière et al.
Haematologica, 100(2), 275-283 (2014-11-27)
Effective immunosuppression is mandatory to prevent graft-versus-host disease and to achieve a successful clinical outcome of hematopoietic stem cell transplantation. Here we tested whether germline single nucleotide polymorphisms in 20 candidate genes related to methotrexate and cyclosporine metabolism and activity
Moazameh Peyrovi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 41-47 (2015-01-13)
Optimization of supramolecular solvent-based microextraction (SSME) of Loratadine and its determination with high-performance liquid chromatography (HPLC) with ultra violet (UV) detection were investigated. A factorial design (FD) and a central composite face-centered (CCF) were applied to evaluate the SSME procedure.
Mitsuko Takahashi et al.
Journal of AOAC International, 97(4), 1195-1201 (2014-08-26)
Components that could be used as indicators for the discrimination of senna (Cassia angustifolia) from other cassia plants contained in health teas were identified, and an analytical method for the components was developed. Our results revealed two components in senna
Kamal Tyagi et al.
Food chemistry, 179, 76-84 (2015-02-28)
Folates are essential micronutrients for animals as they play a major role in one carbon metabolism. Animals are unable to synthesize folates and obtain them from plant derived food. In the present study, a high performance liquid chromatography coupled to
Samira Hosseini et al.
Biosensors & bioelectronics, 69, 257-264 (2015-03-15)
Electrospun polyhydroxybutyrate (PHB) fibers were dip-coated by polymethyl methacrylate-co-methacrylic acid, poly(MMA-co-MAA), which was synthesized in different molar ratios of the monomers via free-radical polymerization. Fabricated platfrom was employed for immobilization of the dengue antibody and subsequent detection of dengue enveloped
Aixue Dong et al.
International journal of biological macromolecules, 79, 353-362 (2015-05-20)
Enzymatic grafting of synthetic molecules onto lignins provides a mild and eco-friendly alternative for the functionalization of lignocellulosic materials. In this study, laccase-mediated grafting of octadecylamine (OA) onto lignin-rich jute fabrics was investigated for enhancing the surface hydrophobicity. First, the
Iuliana Moldoveanu et al.
Journal of molecular recognition : JMR, 27(11), 653-658 (2014-10-04)
Multimode sensing was proposed for molecular screening and recognition of HER-1 in whole blood. The tools used for molecular recognition were platforms based on nanostructured materials such as the complex of Mn(III) with meso-tetra (4-carboxyphenyl) porphyrin, and maltodextrin (dextrose equivalence
G K Surya Prakash et al.
Science (New York, N.Y.), 338(6112), 1324-1327 (2012-12-12)
Fluoroform (CF(3)H), a large-volume by-product of the manufacture of Teflon, refrigerants, polyvinylidene fluoride (PVDF), fire-extinguishing agents, and foams, is a potent and stable greenhouse gas that has found little practical use despite the growing importance of trifluoromethyl (CF3) functionality in
Daiane Cristina Sass et al.
The Journal of organic chemistry, 77(20), 9374-9378 (2012-09-20)
The solvent has a significant influence in the rate of reactions promoted by Stryker's reagent. The reactions performed in THF were, in most cases, faster than in toluene.
Nathalie M Pinkerton et al.
Advanced healthcare materials, 4(9), 1376-1385 (2015-05-01)
Magnetic resonance imaging (MRI)- and near-infrared (NIR)-active, multimodal composite nanocarriers (CNCs) are prepared using a simple one-step process, flash nanoprecipitation (FNP). The FNP process allows for the independent control of the hydrodynamic diameter, co-core excipient and NIR dye loading, and
Kenneth F Ilett et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(9), 1005-1012 (2002-08-09)
The aim of this study was to elucidate the metabolic pathways for dihydroartemisinin (DHA), the active metabolite of the artemisinin derivative artesunate (ARTS). Urine was collected from 17 Vietnamese adults with falciparum malaria who had received 120 mg of ARTS
Hiroki Tanimoto et al.
Dalton transactions (Cambridge, England : 2003), 44(26), 11811-11818 (2015-06-09)
The stepwise syntheses of germa[N]pericyclynes, including [5]pericyclynes, and their characterization are described. The yields of germa[4] and [8]pericyclynes were improved significantly compared to those obtained in previous studies. The routes reported herein afforded the novel germa[5] and [10]pericyclynes, which were
Jenny P Rosengren-Holmberg et al.
Biomaterials science, 3(8), 1208-1217 (2015-07-30)
Heparin-imprinted synthetic polymer surfaces with the ability to attenuate activation of both the complement and the coagulation system in whole blood were successfully produced. Imprinting was achieved using a template coated with heparin, a highly sulfated glycosaminoglycan known for its
Maria Laura Pati et al.
BMC cancer, 17(1), 51-51 (2017-01-15)
Despite considerable efforts by scientific research, pancreatic cancer is the fourth leading cause of cancer related mortalities. Sigma-2 receptors, which are overexpressed in several tumors, represent promising targets for triggering selective pancreatic cancer cells death. We selected five differently structured
Debby P Chang et al.
Journal of pharmaceutical sciences, 104(10), 3404-3417 (2015-06-24)
Achieving long-term drug release from polymer-based delivery systems continues to be a challenge particularly for the delivery of large hydrophilic molecules such as therapeutic antibodies and proteins. Here, we report on the utility of an in situ-forming and injectable polymer-solvent
Dong Youn Yoo et al.
ACS nano, 8(5), 4248-4256 (2014-04-17)
We have demonstrated the preparation of white-emissive conjugated polymer nanoparticles wrapped with graphene oxide (GO) nanosheets. Highly stable, GO-wrapped, poly(9,9-di-n-octylfluorenyl-2,7-diyl) nanoparticles (GO-PFO NPs) with diameters in the range 30-150 nm were successfully obtained by utilizing the GO nanosheets as an
Claudia Grajeda-Iglesias et al.
Food chemistry, 194, 749-757 (2015-10-17)
Hibiscus sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyces, which are usually discarded. Nevertheless, they represent a potential source of natural bioactive compounds, e.g. polyphenols, which could add value to this under-exploited
Masashi Hasegawa et al.
Beilstein journal of organic chemistry, 11, 972-979 (2015-07-23)
A novel tetrathiafulvalene dimer, bridged by a chiral 1,3-diphenylallene framework, has been prepared as an optically active compound having strong chiroptical properties. Although a chiral allene bearing strong electron-donating group(s) often undergoes slow photoracemization even in daylight, the present allene
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