CN

Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

Macromolecular bioscience (2014-10-22)

Michelle A Ouimet, Renata Fogaça, Sabrina S Snyder, Sameer Sathaye, Luiz H Catalani, Darrin J Pochan, Kathryn E Uhrich

摘要

Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro release studies demonstrated that the chemically incorporated drug (SA) was released from the polymer blends over 3-4 d in contrast to 3 h, and that blends of higher PVP content displayed greater swelling values and faster SA release. The polymer blends significantly the inflammatory cytokine, TNF-α, in vitro without negative effects.

材料

货号

品牌

产品描述

Sigma-Aldrich

二甲基亚砜, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

二甲基亚砜, for molecular biology

Sigma-Aldrich

二甲基亚砜, anhydrous, ≥99.9%

Sigma-Aldrich

四氢呋喃, anhydrous, ≥99.9%, inhibitor-free

Sigma-Aldrich

四氢呋喃, inhibitor-free, suitable for HPLC, ≥99.9%

Sigma-Aldrich

二甲基亚砜, ACS reagent, ≥99.9%

Sigma-Aldrich

四氢呋喃, anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

Sigma-Aldrich

二甲基亚砜, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Sigma-Aldrich

二氯甲烷, anhydrous, ≥99.8%, contains 40-150 ppm amylene as stabilizer

Sigma-Aldrich

二氯甲烷, suitable for HPLC, ≥99.8%, contains amylene as stabilizer

Sigma-Aldrich

三乙基胺, ≥99.5%

Sigma-Aldrich

二氯甲烷, contains 40-150 ppm amylene as stabilizer, ACS reagent, ≥99.5%

Sigma-Aldrich

二甲基亚砜, suitable for HPLC, ≥99.7%

Sigma-Aldrich

吡啶, anhydrous, 99.8%

Sigma-Aldrich

氯仿, contains 100-200 ppm amylenes as stabilizer, ≥99.5%

Sigma-Aldrich

二甲基亚砜, ≥99.5% (GC), suitable for plant cell culture

Sigma-Aldrich

四氢呋喃, contains 250 ppm BHT as inhibitor, ACS reagent, ≥99.0%

Sigma-Aldrich

二甲基亚砜, ReagentPlus^®, ≥99.5%

Sigma-Aldrich

二氯甲烷, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%, contains 50-150 ppm amylene as stabilizer

Sigma-Aldrich

三乙基胺, ≥99%

Sigma-Aldrich

吡啶, ACS reagent, ≥99.0%

Sigma-Aldrich

三乙基胺, puriss. p.a., ≥99.5% (GC)

Sigma-Aldrich

氯仿, anhydrous, ≥99%, contains 0.5-1.0% ethanol as stabilizer

Sigma-Aldrich

L-谷氨酰胺, meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source

Sigma-Aldrich

氯仿, anhydrous, contains amylenes as stabilizer, ≥99%

Supelco

水杨酸, Pharmaceutical Secondary Standard; Certified Reference Material

Sigma-Aldrich

二甲基亚砜, puriss. p.a., ACS reagent, ≥99.9% (GC)

Sigma-Aldrich

二甲基亚砜, meets EP testing specifications, meets USP testing specifications

Sigma-Aldrich

水杨酸, ACS reagent, ≥99.0%

Sigma-Aldrich

氯仿, contains ethanol as stabilizer, ACS reagent, ≥99.8%