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Wenxing Song et al.
ACS biomaterials science & engineering, 3(6), 1027-1038 (2017-06-12)
Curcumin is a promising anticancer drug but its applications in cancer therapy are limited due to its poor solubility, short half-life, and low bioavailability. In this article, we present a curcumin loaded magnetic silk fibroin core-shell nanoparticle system for sustained
Florencia Harari et al.
Thyroid : official journal of the American Thyroid Association, 25(11), 1199-1208 (2015-09-04)
Impaired thyroid function is a common side effect of lithium medication. Recent data indicate that lithium exposure through drinking water, although providing much lower doses than the medication, may also affect thyroid hormone levels. However, the effects in susceptible groups
Judith Grothe et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(4), 1437-1453 (2015-03-21)
Liver impairment, ranging from steatosis to cirrhosis, is frequent in cystic fibrosis (CF) patients and is becoming increasingly significant due to their improved life expectancy. One aspect of hepatic alterations is caused by increased fecal loss of the essential nutrient
Iain M McIntyre et al.
Journal of analytical toxicology, 39(2), 152-155 (2014-12-18)
A 24-year-old man whose medical history was significant for alcohol abuse and depression was found unresponsive in bed. He had several prior suicide attempts with 'pills' and had also been hospitalized for an accidental overdose on a previous occasion. Autopsy
Ottmar Golf et al.
Journal of the American Society for Mass Spectrometry, 26(1), 44-54 (2014-11-09)
Here we present a proof of concept cross-platform normalization approach to convert raw mass spectra acquired by distinct desorption ionization methods and/or instrumental setups to cross-platform normalized analyte profiles. The initial step of the workflow is database driven peak annotation
Hussein Rasool Abid et al.
Nanoscale, 4(10), 3089-3094 (2012-04-26)
Several zirconium-based metal-organic frameworks (Zr-MOFs) have been synthesized using ammonium hydroxide as an additive in the synthesis process. Their physicochemical properties have been characterized by N(2) adsorption/desorption, XRD, SEM, FTIR, and TGA, and their application in CO(2) adsorption was evaluated.
Ana R Ribeiro et al.
Journal of chromatography. A, 1418, 140-149 (2015-10-04)
The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directive 2013/39/EU), substances of
Amy E Clipperton-Allen et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(6), 718-730 (2015-12-04)
Few studies have evaluated the long-term effects of providing environmental resources to mice. This consideration is important given that mice are often maintained in vivaria for months. We evaluated the effects of providing simple cage resources (wood wool, cotton nesting
Ming-Chuan Wang et al.
Analytical and bioanalytical chemistry, 407(5), 1343-1356 (2014-12-10)
Tyrosine phosphorylation is an important regulator of signaling in cellular pathways, and dysregulated tyrosine phosphorylation causes several diseases. Mass spectrometry has revealed the importance of global phosphoproteomic characterization. Analysis of tyrosine phosphorylation by studying the mass-spectrometry (MS)-determined phosphoproteome remains difficult
Avijit Paul et al.
Nanoscale research letters, 10, 140-140 (2015-04-09)
With advancements in nanotechnology, silver has been engineered into a nanometre size and has attracted great research interest for use in the treatment of wounds. Silver nanoparticles (AgNPs) have emerged as a potential alternative to conventional antibiotics because of their
Stef R A Molenaar et al.
Journal of chromatography. A, 1639, 461922-461922 (2021-02-05)
A peak-tracking algorithm was developed for use in comprehensive two-dimensional liquid chromatography coupled to mass spectrometry. Chromatographic peaks were tracked across two different chromatograms, utilizing the available spectral information, the statistical moments of the peaks and the relative retention times
Gozde Unsoy et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(5), 641-648 (2014-06-02)
The use of nanotechnology in cancer treatment offers exciting opportunities, including the possibility of destroying tumors with minimal damage to healthy tissue by novel targeted drug delivery systems. pH differences between healthy and tumor microenvironment provide pH responsive release of
Vinod Vellora Thekkae Padil et al.
Carbohydrate polymers, 121, 468-476 (2015-02-11)
Electrospun nanofibre membranes from blend solutions of deacetylated gum kondagogu and polyvinyl alcohol of various weight proportions were prepared. The electrospun membrane was cross linked by heating at 150°C for 6h and later modified by methane plasma treatment. Membranes were
Krisztina Hitri et al.
Vaccine, 37(29), 3866-3875 (2019-06-05)
In this work, we explore the effects of O-acetylation on the physical and immunological characteristics of the WHO International Standards of Vi polysaccharide (Vi) from both Citrobacter freundii and Salmonella enterica serovar Typhi. We find that, although structurally identical according
Yaxi Hu et al.
Food chemistry, 176, 123-129 (2015-01-28)
A novel biosensor combining molecularly imprinted polymers and surface-enhanced Raman spectroscopy (MIPs-SERS) determines melamine in whole milk. MIPs were synthesized by bulk polymerization of melamine (template), methacrylic acid (functional monomer), ethylene glycol dimethacrylate (cross-linking agent) and 2,2'-azobisisobutyronitrile (initiator). Static and
Michael A Gardner et al.
Journal of analytical toxicology, 39(2), 118-125 (2014-12-11)
Fentanyl is a synthetic narcotic anesthetic ∼80-100 times more potent than morphine. Owing to the potential for its abuse, the drug may be included in a forensic toxicology work-up, which requires fast, precise and accurate measurements. Here, the stability of
Ravi Chand Bollineni et al.
The Analyst, 140(24), 8109-8117 (2015-11-07)
Depletion of highly abundant proteins is an approved step in blood plasma analysis by mass spectrometry (MS). In this study, we explored a precipitation and differential protein solubility approach as a fractionation strategy for abundant protein removal from plasma. Total
Ji-Wook Kim et al.
Nature protocols, 12(9), 1871-1889 (2017-08-18)
Spatiotemporal interrogation of signal transduction at the single-cell level is necessary to answer a host of important biological questions. This protocol describes a nanotechnology-based single-cell and single-molecule perturbation tool, termed mechanogenetics, that enables precise spatial and mechanical control over genetically
Joanna H Clark et al.
Journal of the American Chemical Society, 133(4), 1016-1032 (2010-12-17)
Charge transfer between metal ions occupying distinct crystallographic sublattices in an ordered material is a strategy to confer visible light absorption on complex oxides to generate potentially catalytically active electron and hole charge carriers. CaCu3Ti4O12 has distinct octahedral Ti4+ and
Johongir M Muradov et al.
Experimental neurology, 249, 59-73 (2013-08-28)
The mechanisms contributing to axon loss after spinal cord injury (SCI) are largely unknown but may involve microvascular loss as we have previously suggested. Here, we used a mild contusive injury (120 kdyn IH impactor) at T9 in rats focusing
Caroline Strasinger et al.
Journal of pharmaceutical sciences, 103(6), 1829-1838 (2014-05-03)
Oral dosage forms and traditional transdermal patches are inadequate for complex clonidine therapy dosing schemes, because of the variable dose/flux requirement for the treatment of opioid withdrawal symptoms. The purpose of this study was to evaluate the in vitro transdermal
Mohammad Saraji et al.
Journal of chromatography. A, 1366, 24-30 (2014-09-28)
A magnesium-aluminum layered double hydroxide coated on magnetic nanoparticles was synthesized and used as a sorbent to extract some phenolic acids including p-hydroxy benzoic acid, caffeic acid, syringic acid, p-coumaric acid and ferulic acid from fruit juices. After extraction, the
Alexandre Grand-Guillaume Perrenoud et al.
Journal of chromatography. A, 1262, 205-213 (2012-09-25)
While neutral and acidic compounds are well separated by supercritical fluid chromatography (SFC), basic analytes are more challenging to separate and often problems occur with their peak shapes. Two different methods were explored in the present paper to reduce these
Mei-Quan Cai et al.
Environmental science and pollution research international, 22(3), 1854-1867 (2014-09-10)
A simultaneous determination method of 14 multi-class pharmaceuticals using solid-phase extraction (SPE) followed by high-performance liquid chromatography-tandem mass spectrometer (HPLC-MS/MS) was established to measure the occurrence and distribution of these pharmaceuticals in tap water and a drinking water treatment plant
Binnian Wei et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 290-297 (2014-06-27)
Most sample preparation methods characteristically involve intensive and repetitive labor, which is inefficient when preparing large numbers of samples from population-scale studies. This study presents a robotic system designed to meet the sampling requirements for large population-scale studies. Using this
Bruno Pinto et al.
Neuron, 108(5), 887-904 (2020-10-08)
Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the
Emily K Cushnie et al.
PloS one, 9(7), e101627-e101627 (2014-07-16)
With greater than 500,000 orthopaedic procedures performed in the United States each year requiring a bone graft, the development of novel graft materials is necessary. We report that some porous polymer/ceramic composite scaffolds possess intrinsic osteoinductivity as shown through their
Bojan Mitrovic et al.
Langmuir : the ACS journal of surfaces and colloids, 29(2), 696-700 (2012-12-19)
A cationic polymer nanobrush was synthesized, attached to a MALDI target, and used for the fractionation of peptides and proteins based on their pI, prior to analysis by MALDI-MS. The cationic polymer nanobrush was synthesized on a gold substrate by
Ahmad Umar et al.
Dalton transactions (Cambridge, England : 2003), 44(48), 21081-21087 (2015-11-26)
Herein, we report the development of a simple and highly sensitive hydroquinone (HQ) chemical sensor based on an electrochemically activated iron-doped (Fe-doped) zinc oxide nanorod (ZnO NR) modified screen-printed electrode (SPE). The Fe-doped ZnO NRs were prepared using a hydrothermal
Organic-aqueous crossover coating process for the desmopressin orally disintegrating microparticles.
Ju-Young Kim et al.
Drug development and industrial pharmacy, 41(2), 292-299 (2013-11-21)
The purpose of the present study was to prepare desmopressin orally disintegrating microparticles (ODMs) using organic-aqueous crossover coating process which featured an organic sub-coating followed by an aqueous active coating. Sucrose beads and hydroxypropyl cellulose (HPC) were used as inert
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