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30-3280
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Yoon Kyung Kwon et al.
Chemical & pharmaceutical bulletin, 63(12), 1076-1080 (2015-12-04)
The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis Koehne showed the highest ChAT-activating effect in vitro in an assay that used
Rachel Morrison et al.
Pharmaceutical research, 31(10), 2904-2917 (2014-05-06)
To design and synthesize chemoembolization particles for the delivery of Ophiobolin A (OphA), a promising fungal-derived chemotherapeutic, directly at the tumour location. To investigate cell death mechanism of OphA on a Rhabdomyosarcoma cancer (RD) cell line. Rhabdomyosarcoma is the most
Zeynep Altintas et al.
Biosensors & bioelectronics, 74, 996-1004 (2015-08-13)
Comparative and comprehensive investigations for adenovirus recognition and detection were conducted using plastic and natural antibodies to compare three different strategies. The implementation of molecularly imprinted polymer (MIP) technology for specific and sensitive recognition of viruses with the combination of
James R Reed et al.
Biochemistry, 52(23), 4003-4013 (2013-05-17)
The goal of this study was to characterize the effects of CYP1A2·CYP2B4 complex formation on the rates and efficiency of toluene metabolism by comparing the results from simple reconstituted systems containing P450 reductase (CPR) and a single P450 to those
Zahra Helalat-Nezhad et al.
Journal of chromatography. A, 1394, 46-53 (2015-04-11)
A novel sample preparation method based on the complete dissolution of marine biological samples in choline chloride-oxalic acid (ChCl-Ox) deep eutectic solvent was developed for fast and efficient extraction of eight polycyclic aromatic hydrocarbons (PAHs) using minimum volumes of cyclohexane.
Salim Sioud et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2389-2397 (2014-10-11)
The formation of ions during atmospheric pressure photoionization (APPI) mass spectrometry in the positive mode usually provides radical cations and/or protonated species. Intriguingly, during the analysis of some N-alkyl-substituted thieno[3,4-c]pyrrole-4,6-dione (TPD) derivatives synthesized in our laboratory, unusual [M-H](+) ion peaks
Banu Koz et al.
International journal of molecular sciences, 9(3), 383-393 (2009-03-28)
A new polyacetylene derivative with electroactive thiophene substituent, namely poly(2-methylbut-2-enyl thiophene-3-carboxylate) was synthesized and characterized. For this purpose, novel acetylene monomer was synthesized by the reaction of 3-thiophenecarboxylic acid with propargyl bromide and polymerized with a Rh catalyst to give
María Teresa Rivera-García et al.
Psychopharmacology, 232(20), 3797-3808 (2015-08-10)
Toluene is a misused inhalant with hallucinogenic properties and complex effects. Toluene blocks N-methyl-D-aspartate (NMDA) receptors, releases dopamine (DA), and modifies several neurotransmitter levels; nonetheless, the mechanism by which it produces hallucinations is not well characterized. This study aims (a)
Reza Esfandiary et al.
Journal of pharmaceutical sciences, 104(2), 577-586 (2014-11-20)
Reversible self-association of protein therapeutics, the phenomenon of formation of native reversible oligomeric species as a result of noncovalent intermolecular interactions, can add additional manufacturing, stability, delivery, and safety complexities in biopharmaceutical development. Its early detection, characterization, and mitigation can
Marina Shalaeva et al.
Journal of medicinal chemistry, 56(12), 4870-4879 (2013-05-29)
This study demonstrates that ΔlogP(oct-tol) (difference between logP(octanol) and logP(toluene)) describes compounds propensity to form intramolecular hydrogen bonds (IMHB) and may be considered a privileged molecular descriptor for use in drug discovery and for prediction of IMHB in drug candidates.
Hoon Hur et al.
PloS one, 9(6), e98581-e98581 (2014-06-10)
The levels of organic acids representing metabolic pathway end products are important indicators of physiological status, and may be associated with metabolic changes in cancer. The aim of this study is to investigate the levels of organic acids in cancerous
Wararat Sriprapat et al.
Ecotoxicology and environmental safety, 102, 147-151 (2014-02-18)
Air borne uptake of toluene and ethylbenzene by twelve plant species was examined. Of the twelve plant species examined, the highest toluene removal was found in Sansevieria trifasciata, while the ethylbenzene removal from air was with Chlorophytum comosum. Toluene and
Matthew R Jacobs et al.
Journal of chromatography. A, 1421, 123-128 (2015-11-26)
Planar microfluidic devices coupled with modern electronic pressure control have allowed gas chromatography (GC) practitioners to easily manipulate chromatographic systems to achieve heart cut and back-flushing configurations. These planar microfluidic devices have enhanced the connectivity between different components of GC
R Cipullo et al.
Dalton transactions (Cambridge, England : 2003), 44(27), 12304-12311 (2015-05-27)
Despite decades of thorough mechanistic investigations, it is still hard to predict the activity of a novel olefin polymerisation catalyst, even when the precursor is a well-defined molecular entity. In the present study, we highlight the crucial importance of activation
Changju Chae et al.
Nanoscale, 7(23), 10368-10376 (2015-05-01)
A wet-chemical, facile strategy is proposed for forming three-dimensional intra-structured nanocomposites to facilitate the development of high performance anodes for lithium ion batteries. The nanocomposites are composed of cobalt oxide nanoparticles, reduced graphene oxides, and Ag nanoparticles, and all the
Jiang-Feng Song et al.
Ultrasonics sonochemistry, 27, 602-608 (2015-05-03)
Ultrasound treatment has been widely applied in the extraction of biologically active compounds including carotenoids. However, there are few reports on their effects on the stability of these compounds. In the present study, the stability of all-trans lutein, one of
Leila Hejazi et al.
Rapid communications in mass spectrometry : RCM, 29(1), 91-99 (2014-12-03)
Mass spectrometric identification of compounds in chromatography can be obtained from molecular masses from soft ionization mass spectrometry techniques such as field ionization (FI) and fragmentation patterns from hard ionization techniques such as electron ionization (EI). Simultaneous detection by EI
Ruiqin Yi et al.
Bioscience, biotechnology, and biochemistry, 79(12), 1931-1945 (2015-08-04)
The convergent synthesis of branched inner-core oligosaccharides of lipopoly- and lipooligosaccharide with a 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) disaccharide acceptor was achieved. The l-glycero-d-manno-heptopyranose (Hep) units for the branched core oligosaccharide Galβ(1-4)Glcβ(1-4)Hep and Hepα(1-3)Hep were prepared from the corresponding Hep building blocks.
Yuanhong Shan et al.
Journal of chromatography. A, 1375, 101-109 (2014-12-17)
To develop a novel hybrid monolithic column based on pentafluorobenzyl imidazolium bromide ionic liquid, a new ionic liquid monomer was synthesized from 1-vinylimidazole and pentafluorobenzyl bromide. By employing a facile one-step copolymerization of polyhedral-oligomeric-silsesquioxane-type (POSS) cross-linking agent and the home-made
Anna Wojakowska et al.
PloS one, 10(9), e0136902-e0136902 (2015-09-09)
Formalin-fixed paraffin-embedded (FFPE) tissue specimens constitute a highly valuable source of clinical material for retrospective molecular studies. However, metabolomic assessment of such archival material remains still in its infancy. Hence, there is an urgent need for efficient methods enabling extraction
Judith van Asperen et al.
Toxicology letters, 138(1-2), 51-62 (2003-02-01)
The toxicity of inhalatory exposure to organic solvents may not only be related to the total external dose, but also to the pattern of exposure. In this study physiologically based toxicokinetic (PBTK) modelling has been used to study the impact
Kwan Wee Tan et al.
ACS nano, 8(5), 4730-4739 (2014-04-02)
Structure control in solution-processed hybrid perovskites is crucial to design and fabricate highly efficient solar cells. Here, we utilize in situ grazing incidence wide-angle X-ray scattering and scanning electron microscopy to investigate the structural evolution and film morphologies of methylammonium
Arash Nikoubashman et al.
ACS nano, 8(8), 8015-8026 (2014-08-12)
We study thin films of homopolymers (PS) and monolayers of cylinder-forming diblock copolymers (PS–PHMA) under shear. To this end, we employed both experiments and computer simulations that correctly take into account hydrodynamic interactions and chain entanglements. Excellent quantitative agreement for
Naif H Alsharif et al.
Small (Weinheim an der Bergstrasse, Germany), 5(2), 221-228 (2008-12-06)
Nanocrystals of various inorganic materials are being considered for application in the life sciences as fluorescent labels and for such therapeutic applications as drug delivery or targeted cell destruction. The potential applications of the nanoparticles are critically compromised due to
Hynek Balcar et al.
Beilstein journal of organic chemistry, 11, 2087-2096 (2015-12-15)
Hoveyda-Grubbs type catalysts with cationic tags on NHC ligands were linker-free immobilized on the surface of lamellar zeolitic supports (MCM-22, MCM-56, MCM-36) and on mesoporous molecular sieves SBA-15. The activity of prepared hybrid catalysts was tested in olefin metathesis reactions:
Ying Cai et al.
Journal of chromatography. A, 1406, 40-47 (2015-07-01)
Fluorenyl functionalized superparamagnetic core/shell magnetic nanoparticles (MNPs, Fe3O4@SiO2@Flu) were prepared and characterized by transmission electron microscope, X-ray diffraction and infrared spectroscopy. The MNPs having an average diameter of 200nm were then used as solid-phase extraction sorbent for the determination of
Kaushik K Rangharajan et al.
Soft matter, 11(26), 5214-5223 (2015-06-05)
Past research has confirmed the existence of surface nanobubbles on various hydrophobic substrates (static contact angle >90°) when imaged in air-equilibrated water. Additionally, the use of solvent exchange techniques (based on the difference in saturation levels of air in various
Vitor L Martins et al.
Physical chemistry chemical physics : PCCP, 17(35), 23041-23051 (2015-08-15)
This work presents the physicochemical characterization of two ionic liquids (ILs) with small phosphonium cations, triethylpenthylphosphonium bis(trifluoromethanesulfonyl)imide ([P2225][Tf2N]) and (2-methoxyethyl)trimethylphosphonium bis(trifluoromethanesulfonyl)imide ([P222(201)][Tf2N]), and their mixtures with Li(+). Properties such as the electrochemical window, density, viscosity and ionic conductivity are presented.
Kyoung-Yong Chun et al.
Nanoscale, 7(29), 12427-12434 (2015-07-02)
Heat-driven ionic gate nanochannels have been recently demonstrated, which exploit temperature-responsive polymer brushes based on wettability. These heat-sensing artificial nanochannels operate in a broad temperature-response boundary and fixed liquid cell environment, thereby experiencing limited system operation in the flat and
Wei Zhao et al.
Small (Weinheim an der Bergstrasse, Germany), 11(35), 4509-4516 (2015-06-04)
The ability to tune gauge factors in terms of magnitude and orientation is important for wearable and conformal electronics. Herein, a sensor device is described which is fabricated by assembling and printing molecularly linked thin films of gold nanoparticles on
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